SRF Publications

If you are looking for an accessible description of SENS research, our Co-founder, Dr Aubrey de Grey, together with co-author Michael Rae, has written a book entitled Ending Aging. The book speaks to a broad audience, but it does so without ‘dumbing down’ the science at all. It is the ideal resource for either the biologist or the non-biologist, whether encountering SENS for the first time or wishing to absorb more of its details. Copies are available from your local bookstore or from The details are: de Grey ADNJ, Rae M. Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime. New York, NY: St. Martin’s Press, 2007, 416pp, hardcover, ISBN 0-312-36706-6; or there is a paperback edition with an additional chapter covering more recent developments, ISBN 0-312-36707-4. Thanks to narrator Stephanie Murphy, there’s now even an audiobook version!

Ending Aging is also available in Spanish, Japanese, German, Italian, and Portuguese (via Amazon Brazil / via Amazon US).

The following list of publications presents work which was funded in whole or in part by SENS Research Foundation.


  • Admasu TD, Kim K, Rae M, Avelar R, Gonciarz RL, Rebbaa A, Pedro de Magalhães J, Renslo AR, Stolzing A, Sharma A. Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis. Cell Rep. 2023 Feb 6;42(2):112058. doi: 10.1016/j.celrep.2023.112058. PubMed: 36753419.


  • Kim K, Admasu TD, Stolzing A, Sharma A. Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells. Aging (Albany NY). 2022 Mar 4;14(undefined). doi: 10.18632/aging.203931. Online ahead of print. PubMed: 35245208

  • Saravanan S, Lewis CJ, Dixit B, O’Connor MS, Stolzing A, Boominathan A. The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics. Biomedicines. 2022 Feb 18;10(2):490. doi: 10.3390/biomedicines10020490. PubMed: 35203698

  • Brauning A, Rae M, Zhu G, Fulton E, Admasu TD, Stolzing A, Sharma A. Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions. Cells. 2022 Mar 17;11(6):1017. doi: 10.3390/cells11061017. PMID: 35326467; PMCID: PMC8947539.


  • Olgasi C, Borsotti C, Merlin S, Bergmann T, Bittorf P, Adewoye AB, Wragg N, Patterson K, Calabria A, Benedicenti F, Cucci A, Borchiellini A, Pollio B, Montini E, Mazzuca DM, Zierau M, Stolzing A, Toleikis PM, Braspenning J, Follenzi A. Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Mol Ther Methods Clin Dev. 2021 Nov 3;23:551-566. doi: 10.1016/j.omtm.2021.10.015. eCollection 2021 Dec 10. PubMed: 34853801
  • Anderson AM, Kirtadze T, Malanga M, Dinh D, Barnes C, Campo A, Clemens DM, Garcia-Fandiño R, Piñeiro Á, O’Connor MS. Cyclodextrin dimers: A versatile approach to optimizing encapsulation and their application to therapeutic extraction of toxic oxysterols. Int J Pharm. 2021 Sep 5;606:120522. PubMed: 33839224
  • Dixit B, Vanhoozer S, Anti NA, O’Connor MS, Boominathan A. Rapid enrichment of mitochondria from mammalian cell cultures using digitonin. MethodsX 2021;8:101197. Document via external site.
  • Admasu TD, Rae M, Stolzing A. Dissecting primary and secondary senescence to enable new senotherapeutic strategies. Ageing Res Rev. 2021 Sep;70:101412. doi: 10.1016/j.arr.2021.101412. Epub 2021 Jul 21. PubMed: 34302996


  • Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. PubMed: 33378272.
  • Wragg NM, Tampakis D, Stolzing A. Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. Int J Mol Sci. 2020 Nov 13;21(22):8579. PubMed: 33203028.
  • Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 Nov;2(11):1265-1283. PubMed: 33199924.
  • Streeter MD, Rowan S, Ray J, McDonald DM, Volkin J, Clark J, Taylor A, Spiegel DA. Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue. ACS Chem Biol. 2020 Sep 25;acschembio.0c00093. PubMed: 32975399.
  • Frasca A, Xue Y, Kossar AP, Keeney S, Rock C, Zakharchenko A, Streeter M, Gorman RC, Grau JB, George I, Bavaria JE, Krieger A, Spiegel DA, Levy RJ, Ferrari G. Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves. JACC Basic Transl Sci. 2020 Aug 5;5(8):755-766. PubMed: 32875167.
  • Stammers M, Niewczas IS, Segonds-Pichon A, Clark J. Mechanical Stretching Changes Cross-Linking and Glycation Levels in the Collagen of Mouse Tail Tendon. J Biol Chem. 2020 Jul 31;295(31):10572-10580. PubMed: 32546479.
  • Stammers M, Ivanova IM, Niewczas IS, Segonds-Pichon A, Streeter M, Spiegel DA, Clark J. Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon. J Biol Chem. 2020 Jul 31;295(31):10562-10571. PubMed: 32381510.
  • Kale A, Sharma A, Stolzing A, Desprez PY, Campisi J. Role of immune cells in the removal of deleterious senescent cells. Immun Ageing 2020 Jun 3;17:16. PubMed: 32518575.
  • Walton CC, Begelman D, Nguyen W, Andersen JK. Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis. Front Cell Neurosci. 2020 May 19;14:129. PubMed: 32508595.
  • Basisty N, Kale A, Patel S, Campisi J, Schilling B. The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications. Expert Rev Proteomics. 2020 Apr;17(4):297-308. PubMed: 32425074.
  • Bansode S, Bashtanova U, Li R, Clark J, Müller KH, Puszkarska A, Goldberga I, Chetwood HH, Reid DG, Colwell LJ, Skepper JN, Shanahan CM, Schitter G, Mesquida P, Duer MJ. Glycation changes molecular organization and charge distribution in type I collagen fibrils. Sci Rep. 2020 Feb 25;10(1):3397. PubMed: 32099005.
  • Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. Cell Chem Biol. 2020 Feb 20;27(2):206-213.e6. PMID: 31767537.
  • Lewis CJ, Dixit B, Batiuk E, Hall CJ, O’Connor MS, Boominathan A. Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes. Redox Biol. 2020 Feb;30:101429. PMID: 31981894.
  • Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 2020 Jan 16;18(1):e3000599. PMID: 31945054.
  • Planque SA, Massey RJ, Paul S. Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg’s uncertainty principle to the verge of medical interventions. Mech Ageing Dev. 2020 Jan;185:111188. PMID: 31783036.
  • Anderson A, Campo A, Fulton E, Corwin A, Jerome WG 3rd, O’Connor MS. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380. PMID: 31926618.


  • Sabbasani VR, Wang KP, Streeter MD, Spiegel DA. One-Step Synthesis of 2,5-Diaminoimidazoles and Total Synthesis of Methylglyoxal-Derived Imidazolium Crosslink (MODIC). Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18913-18917. PMID: 31713976.
  • Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec;25(12):1822-1832. PMID: 31806905.
  • Kim NY, Goddard TN, Sohn S, Spiegel DA, Crawford JM. Biocatalytic Reversal of Advanced Glycation End Product Modification. Chembiochem. 2019 Sep 16;20(18):2402-2410. PMID: 31013547.
  • West MD, Sternberg H, Labat I, Janus J, Chapman KB, Malik NN, de Grey AD, Larocca D. Toward a unified theory of aging and regeneration. Regen Med. 2019 Sep;14(9):867-886. PMID: 31455183.
  • Halioua-Haubold CL, Jolly JK, Smith JA, Pinedo-Villanueva R, Brindley DA, MacLaren RE. Potential lifetime quality of life benefits of choroideremia gene therapy: projections from a clinically informed decision model. Eye (Lond). 2019 Aug;33(8):1215-1223. PMID: 31312000.
  • Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van ‘t Veer LJ, Campisi J, Coppé JP. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019 Jun 11;5. PMID: 31184599.
  • Moody KJ. A Translational Approach to Enzyme-Mediated Retinal Lipofuscin Removal for Atrophic Age-Related Macular Degeneration and Stargardt’s Disease (2019). Open Access Dissertations. 2261. Document via external site.
  • Ng KS, Smith JA, McAteer MP, Mead BE, Ware J, Jackson FO, Carter A, Ferreira L, Bure K, Rowley JA, Reeve B, Brindley DA, Karp JM. Bioprocess decision support tool for scalable manufacture of extracellular vesicles. Biotechnol Bioeng. 2019 Feb;116(2):307-319. PMID: 30063243.
  • West MD, Chang CF, Larocca D, Li J, Jiang J, Sim P, Labat I, Chapman KB, Wong KE, Nicoll J, Van Kanegan MJ, de Grey ADNJ, Nasonkin IO, Stahl A, Sternberg H. Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells. Stem Cell Res Ther. 2019 Jan 8;10(1):7. PMID: 30616682.


  • Lam C, Meinert E, Alturkistani A, Carter AR, Karp J, Yang A, Brindley D, Cui Z. Decision Support Tools for Regenerative Medicine: Systematic Review. J Med Internet Res. 2018 Dec 19;20(12):e12448. PMID: 30567696.
  • Meinert E, Van Velthoven M, Brindley D, Alturkistani A, Foley K, Rees S, Wells G, de Pennington N. The Internet of Things in Health Care in Oxford: Protocol for Proof-of-Concept Projects. JMIR Res Protoc. 2018 Dec 4;7(12):e12077. PMID: 30514695.
  • Moody KJ, Tinklepaugh J, Obert E, Grohn K, DeRosa JR, Lumen E, Moyer BS, Campbell S, Wolfe AJ, Sleeper MB, Bianchi AH, Fisher C, Applegate J, Leary E, LeClair N, Wortel D, Doyle RP, Rohrer B, Blanden AR. Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt’s Macular Degeneration Models. Rejuvenation Res. 2018 Dec;21(6):560-571. PMID: 30516450.
  • Meinert E, Alturkistani A, Brindley D, Knight P, Wells G, de Pennington N. Weighing benefits and risks in aspects of security, privacy and adoption of technology in a value-based healthcare system. BMC Med Inform Decis Mak. 2018 Nov 13;18(1):100. PMID: 30424753.
  • Smith JA, Arshad Z, Trippe A, Collins GS, Brindley DA, Carr AJ. The Reporting Items for Patent Landscapes statement. Nat Biotechnol. 2018 Nov 9;36(11):1043-1047. PMID: 30412195.
  • Chow WY, Li R, Goldberga I, Reid DG, Rajan R, Clark J, Oschkinat H, Duer MJ, Hayward R, Shanahan CM. Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR. Chem Commun (Camb). 2018 Nov 6;54(89):12570-12573. PubMed: 30299444.
  • Meinert E, Alturkistani A, Car J, Carter A, Wells G, Brindley D. Real-world evidence for postgraduate students and professionals in healthcare: protocol for the design of a blended massive open online course. BMJ Open. 2018 Oct 4;8(9):e025196. PMID: 30287615.
  • Alturkistani A, Majeed A, Car J, Brindley D, Wells G, Meinert E. Health information technology uses for primary prevention in preventive medicine: a scoping review protocol. BMJ Open. 2018 Oct 4;8(9):e023428. PMID: 30287611.
  • Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ. Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. PMID: 30150385.
  • Meinert E, Alturkistani A, Brindley D, Carter A, Wells G, Car J. Protocol for a mixed-methods evaluation of a massive open online course on real world evidence. BMJ Open. 2018 Aug 13;8(8):e025188. PMID: 30104321.
  • Osama T, Brindley D, Majeed A, Murray KA, Shah H, Toumazos M, Van Velthoven M, Car J, Wells G, Meinert E. Teaching the relationship between health and climate change: a systematic scoping review protocol. BMJ Open. 2018 May 20;8(5):e020330. PMID: 29780026.
  • Pettitt D, Arshad Z, Smith J, Stanic T, Holländer G, Brindley D. CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape. Mol Ther. 2018 Feb 7;26(2):342-353. PMID: 29248427.


  • Halioua-Haubold CL, Peyer JG, Smith JA, Arshad Z, Scholz M, Brindley DA, MacLaren RE. Regulatory Considerations for Gene Therapy Products in the US, EU, and Japan. Yale J Biol Med. 2017 Dec 19;90(4):683-693. PMID: 29259533.
  • Vijg J, Gravina S, Dong X. Intratissue DNA methylation heterogeneity in aging. Chapter 9 in Epigenetics of Aging and Longevity: Translational Epigenetics, Volume 4 (Moskalev A, Vaiserman AM, eds.). Academic Press (2017), pp 201-212.
  • Davies BM, Smith J, Rikabi S, Wartolowska K, Morrey M, French A, MacLaren R, Williams D, Bure K, Pinedo-Villanueva R, Mathur A, Birchall M, Snyder E, Atala A, Reeve B, Brindley D. A quantitative, multi-national and multi-stakeholder assessment of barriers to the adoption of cell therapies. J Tissue Eng. 2017 Aug 11;8:2041731417724413. PMID: 28835816.
  • Yu B, Dong X, Gravina S, Kartal Ö, Schimmel T, Cohen J, Tortoriello D, Zody R, Hawkins RD, Vijg J. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation. Stem Cell Reports. 2017 Jul 11;9(1):397-407. PMID: 28648898.
  • Pettitt D, Arshad Z, Davies B, Smith J, French A, Cole D, Bure K, Dopson S, DiGiusto D, Karp J, Reeve B, Barker R, Holländer G, Brindley D. An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol. Syst Rev. 2017 Jun 26;6(1):120. PMID: 28651620.
  • Gaspar J, Mathieu J, Alvarez P. 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway. Sci Rep. 2017 May 19;7(1):2197. PMID: 28526856.
  • Liu Y, Conboy I. Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3. Skelet Muscle. 2017 May 15;7(1):7. PMID: 28506310.
  • Perrott KM, Wiley CD, Desprez PY, Campisi J. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience. 2017 Apr;39(2):161-173. PubMed: 28378188.
  • Smith JA, Arshad Z, Thomas H, Carr AJ, Brindley DA. Evidence of insufficient quality of reporting in patent landscapes in the life sciences. Nat Biotechnol. 2017 Mar 7;35(3):210-214. PMID: 28267720.
  • Meretoja VV, Paul S, Planque SA. Hydrolysis and Dissolution of Amyloids by Catabodies. Methods Mol Biol. 2017;1643:111-134. PMID: 28667533.
  • Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nat Biomed Eng. 2017;1:889-901. PMID: 29805845.


  • Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, Conboy IM. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun. 2016 Nov 22;7:13363. PubMed: 27874859.
  • Boominathan A, Vanhoozer S, Basisty N, Powers K, Crampton AL, Wang X, Friedricks N, Schilling B, Brand MD, O’Connor MS. Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant. Nucleic Acids Res. 2016 Sep 4. PubMed: 27596602.
  • Gravina S, Dong X, Yu B, Vijg J. Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome. Genome Biol. 2016 Jul 5;17(1):150. PubMed: 27380908.
  • Pettitt DA, Smith J, Meadows N, Arshad Z, Schuh A, DiGustio D, Bountra C, Holländer G, Barker R, Brindley DA. Regulatory barriers to the advancement of precision medicine. Expert Review of Precision Medicine and Drug Development 1: 319-329. Read on external site.
  • Pettitt DA, Smith J, Fuzerstenau-Sharp M, Holländer G, Predki P, Slade A, Jones P, Weed L, Bure K, Brindley DA. Emerging Platform Bioprocesses for Viral Vectors and Gene Therapies. BioProcess International 14(4)s. Read on external site.
  • Bure K, Ball A, Biagioni K, Mehta S, Choudhary R, Arshad Z, Pettitt DA, Holländer G, Al-Mossawi H, Faulstich F, Reeve B, Smith JA, Brindley DA. Automation of CAR-T Cell Adoptive Immunotherapy Bioprocessing. BioProcess International 14(4)s. Read on external site.
  • Pettitt DA, Raza S, Naughton B, Roscoe A, Ramakrishnan A, Ali A, Davies B, Dopson S, Hollander G, Smith J, Brindley DA. The Limitations of QALY: A Literature Review. J Stem Cell Res Ther 6:334. Read on external site.
  • Arshad Z, Smith J, Roberts M, Lee WH, Davies B, Bure K, Hollander GA, Dopson S, Bountra C, Brindley D. Open Access Could Transform Drug Discovery: A Case Study of JQ1. Expert Opin Drug Discov. 2016 Mar;11(3):321-32. PubMed: 26791045.
  • Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 23(2):303-14. PubMed: 26686024.
  • Gaspar J, Mathieu J, Alvarez PJJ. A Rapid Platform to Generate Lipofuscin and Screen Therapeutic Drugs for Efficacy in Lipofuscin Removal. Materials, Methods & Technologies, Volume 10, 2016. Read on external site.
  • Naughton BD, Smith JA, Brindley DA. Establishing good authentication practice (GAP) in secondary care to protect against falsified medicines and improve patient safety. Eur J Hosp Pharm doi:10.1136/ejhpharm-2015-000750. Read on external site.
  • Smith JA, French A, Hurley H, Davies B, Dopson S, Fairchild P, Roberts M, Riley P, Reeve B, Williams D, Daheron L, Bure K, Carr A, Karp JM, Wall I, Brindley D. Challenges and Opportunities in the Development of Induced Pluripotent Stem Cell Therapeutics. In: Frontiers in Stem Cell and Regenerative Medicine Research, Volume II. Bentham Science (in press). Read on external site.
  • Smith JA, Dopson S, Davies B, Wartolowska K, Karp JM, Carr AJ, Brindley DA. Borderline Regulation of Stem Cell Technologies: Therapies, Devices and Combination Products. In: Global Device Strategy. Regulatory Affairs Professionals Society (in press).
  • Luo D, Smith JA, Meadows NA, Manescu K, Bure K, Davies B, Horne R, DiGiusto DL, Brindley DA. A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics. Front. Genet. 6:357. Read on external site.


  • Rekhi R, Smith JA, Arshad Z, Roberts M, Bountra C, Bingham I, Bure K, Brindley DA. Decision-Support Tools for Monoclonal Antibody and Cell Therapy Bioprocessing: Current Landscape and Development Opportunities. BioProcess Executive 13(11). Read on external site.
  • Lannon KA, Smith JA, Bure K, Brindley DA. Quantitative Risk Assessment of Bioaccumulation Attributable to Extractables and Leachables in Cellular Immunotherapy Biomanufacturing. BioProcess International. (Nov 2015) Read on external site.
  • Carmen J, Brindley DA, Davie NL, Smith D. Cell Therapy Manufacturing: Identifying and Meeting Demand. In: Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies. Wiley-Blackwell (2015). Read on external site.
  • Draghici C, Wang T, Spiegel DA. Concise total synthesis of glucosepane. Science 2015;350(6258):294-298. doi:10.1126/science.aac9655. PubMed: 26472902.
  • Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O’Malley TT, Solomon A, Walsh DM, O’Nuallain B. IgG Conformer’s Binding to Amyloidogenic Aggregates. PLoS One. 2015 Sep 14;10(9):e0137344. doi: 10.1371/journal.pone.0137344. PubMed: 26367058.
  • Brindley DA, Arshad Z, Luo D, Dopson S, Hollander G, Frost S, Bountra C, Smith JA. 21(st) Century Cures Act: An Act of Cure or Diagnosis? Rejuvenation Res. 2015 Aug;18(4):295-8. PubMed: 26291241.
  • Hughes BB, Kuhn R, Margolese-Malina ES, Rothman DS, Solórzano JR. Opportunities and challenges of a world with negligible senescence. Technol. Forecast. Soc. Change 99:77-91 (2015). Read on external site.
  • Gravina S, Ganapathi S, Vijg J. Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns. Nucleic Acids Res. 2015 Apr 19. pii: gkv366. PubMed: 25897117.
  • Brindley DA, Rekhi R, Fuerstenau-Sharp M, Kantoff PW, Hollander GA, Smith JA, Tindal S, Timmins N, Bure K. The Potential Application of Real Time Release Testing for the Biomanufacture of Autologous Cell Based Immunotherapies. BioProcess International. 13(4):1-8. Read on external site.
  • Smith JA, Ng KS, Mead BE, Dopson S, Reeve B, Edwards J, Wood MJA, Carr AJ, Bure K, Karp JM, Brindley DA. Extracellular Vesicles: Commercial Potential As Byproducts of Cell Manufacturing for Research and Therapeutic Use. BioProcess International. 13(4). Read on external site.
  • Silva H, Halvorsen D, Henson JD. Control ALT, Delete Cancer The Scientist (magazine). Read on external site.
  • French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem Cells Transl Med. 2015 Mar;4(3):217-23. PubMed: 25650438.
  • Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ, Williams D, Kim HW, French A, Coffey PJ, Cooper-White JJ, Reeve B, Rao M, Snyder EY, Ng KS, Mead BE, Smith JA, Karp JM, Brindley DA, Wall I. Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies. Cell Stem Cell. 2015 Jan 8;16(1):13-7. PubMed: 25575079.
  • Smith JA, Naughton B, Kramm A, Smith G, Ohanjanyan A, De Simone M, Horne R, Brindley DA. European Union Falsified Medicines Directive: Requirements and Implications for Multi-Stakeholder Healthcare Delivery. Chapter 8 in Fundamentals of EU Regulatory Affairs, 7th Edition. Regulatory Affairs Professionals Society. Read on external site.
  • Smith JA, Bravery CA, Hollander G, Brindley DA. Regulating Regenerative Medicine: Cell Therapy, Gene Therapy and Tissue Engineering. Chapter 29 in Fundamentals of EU Regulatory Affairs, 7th Edition. Regulatory Affairs Professionals Society. Read on external site.
  • Smith JA, Reeve B, Carr A, Brindley DA. Regulating Regenerative Medicine: Cell Therapy, Gene Therapy and Tissue Engineering. Chapter 31 in Fundamentals of US Regulatory Affairs, 9th Edition. Regulatory Affairs Professionals Society. Read on external site.


  • Soland MA, Keyes LR, Bayne R, Moon J, Porada CD, St Jeor S, Almeida-Porada G. Perivascular stromal cells as a potential reservoir of human cytomegalovirus. Am J Transplant. 2014 Apr;14(4):820-30. doi: 10.1111/ajt.12642. Epub 2014 Mar 4 PubMed: 24592822.
  • Meadows NA, Morrison A, Brindley DA, Schuh A, Barker RW. An evaluation of regulatory and commercial barriers to stratified medicine development and adoption. Pharmacogenomics J. 2015 Feb;15(1):6-12. doi: 10.1038/tpj.2014.51. Epub 2014 Oct 7. PubMed: 25287070.
  • Davies BM, Rikabi SR, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K, Brindley DA. Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. J Tissue Eng. 2014 Sep 19;5:2041731414551764. doi: 10.1177/2041731414551764. eCollection 2014. PubMed: 25383173.
  • Smith G, Smith JA, Brindley DA. The Falsified Medicines Directive: How to secure your supply chain. J Generic Med. 2014 Sep;11(3-4):169-172. PubMed: 26435721.
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Prior to the establishment of SENS Research Foundation as an independent non-profit in 2009, research into SENS was supported by the Methuselah Foundation.

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  • Ellouze S, Augustin S, Bouaita A, Bonnet C, Simonutti M, Forster V, Picaud S, Sahel JA, Corral-Debrinski M. Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am J Hum Genet. 2008 Sep;83(3):373-87. doi: 10.1016/j.ajhg.2008.08.013. PubMed: 18771762.
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  • Rittmann BE, Schloendorn J. Engineering away lysosomal junk: medical bioremediation. Rejuvenation Res 2007;10(3):359-365. PubMed: 17708688.
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