COVID-19 and Aging
Why is the novel coronavirus so deadly to the elderly? We outline some of the ways in which aging is relevant to diseases like COVID-19 – and how our research may help render future viruses far less dangerous.
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Question of the Month #12: Energy-Carrying Molecules to Boost Aging Mitochondria?
Question of the Month #12: Energy-Carrying Molecules to Boost Aging Mitochondria? Part of Michael Rae’s regular column from the Foundation’s newsletter.
The Neuroprotector’s Dilemma: A Potential Neuroprotective Agent with a Janus Face
Rejuvenation of the aging brain will require the integrated application of several core rejuvenation biotechnologies, including notably those that remove intra- and extraneuronal aggregates implicated in neurodegenerative aging and mature cell therapy. Numerous aggregate-clearing rejuvenation biotechnologies are now in human trials, whereas mature cell therapy for the brain is a more challenging goal and will not be available for some time. In this context, an alternative approach to maintaining the viability of aging neurons could complement aggregate-clearing therapies to preserve neurons until neural replacement and reinforcement matures. In this post we explore the potential of one recently-emerged approach: inhibition of the unfolded protein response (UPR).
2013 SRF Summer Scholar Profile: Meredith Giblin
Meredith Giblin is a senior at Rensselaer Polytechnic Institute (RPI) in Troy, NY, where she is majoring in Biochemistry and Biophysics. During her first three years at RPI, Meredith worked in the laboratories of Dr. Robert Linhardt and Dr. Patrick Maxwell. While in the Linhardt lab, she optimized an endotoxin purification protocol as part of …
2016 SRF Summer Scholar Profile: Isha Bagga
My name is Isha Bagga, and I am a rising junior at University of California, Los Angeles studying physiological sciences. When I found the SENS Research Foundation, I thought it would be exciting to join because everyone was working on many new concepts in aging. I find this very intriguing because that is one physical …
A TAME Attempt to Slow Aging Part 5: Winning the Game with a Weak Hand
Metformin has been proposed as an “anti-aging drug,” and scientists are organizing TAME, a major clinical trial to test the idea. In the final installment of this 5-part series, we look at TAME itself: how it’s structured, how it’s justified, and how the results could impact the push for longevity therapeutics.
Toward Regenerative Medicine Against Atherosclerosis
SENS Foundation-funded research shows that expression of a modified microbial enzyme protects human cells against 7-ketocholesterol toxicity, advancing research toward remediation of the foam cell and rejuvenation of the atherosclerotic artery.
2020 SRF Summer Scholar Profile: Kaitlin Pensabene
My name is Kaitlin Pensabene, and I am a senior at Villanova University studying biochemistry. At Villanova, I work with Dr. Aimee Eggler studying the effects of small molecule antioxidants on the Nrf2/ARE pathway. Specifically, I have been studying not only how transcriptional but also how translational processes are attenuated by oxidative stress. In doing …
ApoptoSENS: Removing Dysfunctional Cells
Return to Intro ApoptoSENS Removing Dysfunctional Cells At conception, all of our cells have wide-open potential to develop into many different kinds of cell, including liver, immune, muscle, or brain neuronal cells. But even after progressing into their respective specific types, cells continue to adapt to changing internal and external conditions. Some of these adaptations …
