Senolytics in Aging Muscle: Could the Cure Be Worse than the Disease?

Skeletal muscles are organized into long fibers, and when a fiber breaks the entire fiber is often lost. This made a supporter worry that senolytic therapies might break a muscle fiber and eliminate precious fibers in aging muscles. It appears that the injury at the heart of the questioner’s worry does not happen in practice.

The Neuroprotector’s Dilemma: A Potential Neuroprotective Agent with a Janus Face

Rejuvenation of the aging brain will require the integrated application of several core rejuvenation biotechnologies, including notably those that remove intra- and extraneuronal aggregates implicated in neurodegenerative aging and mature cell therapy. Numerous aggregate-clearing rejuvenation biotechnologies are now in human trials, whereas mature cell therapy for the brain is a more challenging goal and will not be available for some time. In this context, an alternative approach to maintaining the viability of aging neurons could complement aggregate-clearing therapies to preserve neurons until neural replacement and reinforcement matures. In this post we explore the potential of one recently-emerged approach: inhibition of the unfolded protein response (UPR).

COVID-19 and Aging

Why is the novel coronavirus so deadly to the elderly? We outline some of the ways in which aging is relevant to diseases like COVID-19 – and how our research may help render future viruses far less dangerous.

2020 SRF Summer Scholar Profile: Kaitlin Pensabene

My name is Kaitlin Pensabene, and I am a senior at Villanova University studying biochemistry. At Villanova, I work with Dr. Aimee Eggler studying the effects of small molecule antioxidants on the Nrf2/ARE pathway. Specifically, I have been studying not only how  transcriptional but also how translational processes are attenuated by oxidative stress. In doing …

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ApoptoSENS: Removing Dysfunctional Cells

Return to Intro ApoptoSENS Removing Dysfunctional Cells At conception, all of our cells have wide-open potential to develop into many different kinds of cell, including liver, immune, muscle, or brain neuronal cells. But even after progressing into their respective specific types, cells continue to adapt to changing internal and external conditions. Some of these adaptations …

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2013 SRF Summer Scholar Profile: Meredith Giblin

Meredith Giblin is a senior at Rensselaer Polytechnic Institute (RPI) in Troy, NY, where she is majoring in Biochemistry and Biophysics. During her first three years at RPI, Meredith worked in the laboratories of Dr. Robert Linhardt and Dr. Patrick Maxwell. While in the Linhardt lab, she optimized an endotoxin purification protocol as part of …

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2016 SRF Summer Scholar Profile: Isha Bagga

My name is Isha Bagga, and I am a rising junior at University of California, Los Angeles studying physiological sciences. When I found the SENS Research Foundation, I thought it would be exciting to join because everyone was working on many new concepts in aging. I find this very intriguing because that is one physical …

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Do the Hallmarks of Aging Make SENS? (Part Two)

A supporter asks if the Hallmarks of Aging could effectively be substituted for the seven categories of cellular and molecular damage in the SENS platform. The answer is ‘no,’ because the Hallmarks include both too much and too little, and most importantly because the Hallmarks fail to serve as a roadmap toward the biomedical postponement of aging.

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