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SRF is at the center of the rejuvenation biotechnology industry and supports the mission to end age-related disease through Research, Education, and Outreach. Make your career something you can believe in – something that can change the world.

Career Opportunities

Job Opportunity: Research Scientist – MitoSENS

Job Type: Full-time
Title: Research Scientist
Salary: Pay is salaried, commensurate with experience and local rates.

The Opportunity:

SRF is a non-profit organisation globally recognized for its dedication to transforming the way the world researches and treats aging (www.sens.org). We are located in Mountain View, California, in the heart of bay area biotech hub and several premier academic institutions.

Mitochondria are dynamic organelles vital to several functions within the cell. Decline in mitochondrial function is a distinctive feature in several age-related pathologies including sarcopenia, metabolic dysfunctions, and neurodegenerative disorders. It has been observed that, with age, mutations in the mitochondrial DNA accumulate at an order of magnitude higher compared to the nucleus. The Boominathan lab at SENS Research Foundation is developing gene therapies to functionally express the 13 protein coding genes in the mitochondrial genome from the nucleus (also called allotopic expression). We are also interested in modulating the mitochondrial DNA for sustained organelle fitness and function over time. Using disease cell lines and in vivo models, our lab integrates molecular biology, biochemistry, and computational tools in achieving these goals. For project details please see https://sens.org/research/intramural/allotopic-expression.

Key Responsibilities:

This research position is within a collaborative and dynamic group developing transitional therapies for mitochondrial dysfunctions.

  • Plan, design and execute all aspects of preclinical research
  • Analyze data, prepare reports, and present results regularly in internal and external settings
  • Mentor junior staff and maintain day to day functions in the laboratory

Technical Skills and Qualifications:

  • The ideal candidate should have a Ph.D. in biology/ biochemistry/ biomedical/ bioengineering or a related field
  • Proven experience in cell and molecular biology, gene therapy / DNA editing, working with rodent models, and assay development
  • Familiarity in designing large DNA constructs (BAC cloning, artificial chromosomes) is highly desired
    Experience with biomolecule delivery using vesicles, exosomes, nanoparticles, or similar technologies is highly desired
  • Exposure to mitochondria biology is a plus but not required
  • Excellent written and verbal communication skills
  • Excellent interpersonal and organizational skills with the ability to thrive in a goal-driven team environment
  • Excellent analytical and problem-solving skills
  • Ability to plan and document your work diligently
  • Positive spirit, a real drive for science
  • Capacity to adapt as priorities and requirements change

Compensation:

We offer an excellent benefits package including paid vacation and sick leave, fully covered health and dental insurance (inclusive of dependents), an FSA program, and a company-matched 401(k) plan, all of which is offered after a 90-day introductory period. SENS Research Foundation is an equal opportunity employer. We may sponsor a visa for international applicants.

The position is available now and will be filled as soon as qualified candidates are found. Salary is commensurate with job experience.

TO APPLY:

If you are interested in this opportunity, please send a current CV and a letter expressing your interest to [email protected].

Job Opportunity: Research Associate – Senescence Immunology

Job Type: Full-time
Title: Research Associate
Salary: Pay is salaried, commensurate with experience and local rates; typically around $55,000/year.

Qualifications:

  • Master’s (Preferred)
  • Laboratory experience: 1 year (Preferred)
  • Wet chemistry: 1 year (Preferred)

SENS Research Foundation (SRF) is hiring a Research Associate for our Research Center (RC) located in Mountain View, CA. SRF is an exciting, cutting-edge non-profit dedicated to transforming the way the world researches and treats age-related diseases. More detailed information can be found at our website: www.sens.org

We seek a Research Associate (RA) to join our small but dynamic immunology team led by Dr. Amit Sharma for a project geared toward investigating the mechanisms involved in the immune surveillance of senescent cells with the aim of finding promising interventions.

There are three main projects currently for the RA. One of the projects involves characterizing age-dependent phenotypes changes in the of Natural Killer cells and its implication on their ability to eliminate senescent cells in cell culture and mice model. We have identified several unique antigens expressed on the surface of senescent cells. The goal of the second project is to characterize the surface antigens on senescent cells and with the goal of developing CAR-NK cells with therapeutic application. The projects will require validating the CAR-NK cells in cell culture and the mice models of senescence. Senescent cells are known to secrete a unique mixture of proinflammatory cytokines, chemokines and matrix modifying proteins called SASP (Senescence Associated Secretory Phenotype). We have identified several SASP factors that may block immune surveillance by NK cells. The aim of the third project is to develop therapeutic interventions based on removal of these SASP proteins for enhancing immune surveillance of senescent cells in aging and senescence mice model. All these projects involves extensive use of cell culture and mice models and involves working with human blood samples, primary human cells, and mice tissue.

The ideal candidate for this full-time position has a Ph.D. in chemical/biological sciences and substantial (or the master’s degree with at least 1-2 years) bench experience, industry experience position is preferred. The candidate must be adaptable, a team player, self-motivated, and interested in problem-solving. Duties will include performing wet-lab experiments, recording and analyzing data, and presenting the results in meetings every 2-3 months.

The ideal candidate must have experience with molecular biology techniques, such as quantitative real-time PCR, Western blot, immunofluorescence, ELISA, microplate readers, and flow cytometry analysis, as well as prior experience performing data analysis and presenting data. Preference will be given to candidates with experience in primary cell culture and PBMC isolation from human blood.

We offer an excellent benefits package including paid vacation and sick leave, fully covered health and dental insurance (inclusive of dependents), an FSA program, and a company-matched 401(k) plan, all of which is offered after a 90-day introductory period. SENS Research Foundation is an equal opportunity employer. The job offer comes with two years contract with the possibility of an extension. We may sponsor a visa for international applicants.

The position is available now and will be filled as soon as the qualified candidate is found. Salary is commensurate with the job title.

TO APPLY:

Interested candidates should apply by emailing a cover letter and current CV to [email protected].

COVID-19 considerations:

All employees are to follow COVID restrictions, which will lighten as our workplace is vaccinated. All employees are expected to wear PPE. Vaccinating is strongly encouraged.

Please check back soon for more career opportunities.

Students

Current undergraduate students and recent graduates, respectively, can apply to the annual Summer Scholar and Postbaccalaureate Fellowship programs run by SRF Education. These programs are the best way for early-career researchers to get involved with research in rejuvenation biotechnology.

Volunteers

We don’t regularly use volunteers, but if you would like to be added to our Volunteer Directory then contact us to register your interest. To assist us in matching you with future opportunities to help, please include a brief summary of any specific skills or resources you’d be able to offer in support of our mission.

Research Collaborators

If you are a research scientist working in a SENS-related field, you may wish to submit a grant proposal for consideration by our Research Development Committee.

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