SRF Postbaccalaureate Fellowship Program

The SRF Postbaccalaureate Fellowship Program offers recent graduates a gap year option where they can strengthen their research and communication skills in preparation for such opportunities as graduate programs, medical programs, and biotech positions. Like the SRF Summer Scholars Program, the goal of the Postbaccalaureate Fellowship Program includes assignments and training that hones writing and presentation skills. These training exercises are completed within the framework of a research project that the Fellow will be tasked with completing under the guidance of a scientific mentor.

Fellowship Program Training Goals

SRF Education undergraduate programs primarily are designed to address two pressing needs in STEM education: the availability of novel, inquiry-based research opportunities and scientific communication skills. Whether a student plans to pursue postgraduate studies or apply for a research position at a pharmaceutical company, practical experience is key. However, research opportunities are limited at some colleges, and specific fields of research, such as tissue engineering, may be completely absent.

SRF Education sets itself apart from many other training programs with its focus on the development of scientific communication skills in addition to enhancing laboratory and critical thinking skills. Over the course of its educational programs, participants are guided through practical writing assignments that simulate documents scientists are often asked to produce, such as grant proposals. The communication training culminates in a formal presentation at a symposium where participants present the results of their work to their peers and mentors.

Program Learning Objectives Include:

  • Planning and executing an independent research project
  • Learning new technical skills
  • Explaining scientific concepts to a non-scientific audience
  • Submitting a simple grant proposal
  • Presenting results to peers in a formal scientific symposium

Qualifications

  1. Applicants should have some biologically-related prior research experience.
  2. Although GPA will be a consideration, there are no formal GPA requirements.
  3. There are no specific major requirements. Students of any major may apply, provided they can demonstrate experience relevant to the project in question.
  4. As noted in the Eligibility Requirements section, applicants who have earned their bachelor’s degree within the past 2 years are eligible to apply. Thus, the 2020 class of Postbaccalaureate Fellows will consist of graduates from the classes of 2018, 2019, and 2020.
  5. Only international students who can use optional practical training (OPT) work authorization can apply.

Important Dates

  1. The online application will be available on November 1, 2019.
  2. Completed applications are due at NOON PST on Monday, February 17, 2020 (12 pm PST 2/17/20). Be sure to ask for your letter of recommendation well in advance to provide sufficient time for it to be submitted.
  3. Finalists will be contacted by Thursday, April 30, 2020.

Start Date and Duration

  1. The fellowship will start on Tuesday, September 1, 2020, but fellows must be available for HR paperwork on Friday, August 28, 2020.
  2. The fellowship will last 9 months and end on May 31, 2021.

Compensation

  1. Stipend rates will be based upon levels used by government agencies, such as the NIH and NSF.
  2. Fellows will be eligible for benefits after the first 3 months of employment.

Housing

  1. Participants in the program will need to locate their own housing. Advice can be provided by SRF and the host lab. A stipend will be provided to cover room and board costs.

Review the following to confirm your eligibility to participate in the program:

  1. This program is designed for recent college graduates, who earned their bachelor’s degree within the past two years prior to the date they begin the program. For instance, the 2020 class of Postbaccalaureate Fellows will consist of graduates of the classes of 2018, 2019, or 2020.
  2. Students currently enrolled in a master’s, doctoral, medical, or similar postgraduate degree granting program are ineligible to apply. Similarly, any applicant who has already earned a postgraduate degree is ineligible to apply.
  3. Participants in the program also must be able to legally work in the U.S. via citizenship, permanent residency, or optional practical training (OPT). NOTE: Only international students who can use OPT work authorization can apply. Similar programs that fulfill the work visa requirement will be considered on a case-by-case basis.
  4. It is strongly recommended that students using OPT work authorization consult their on-campus advisors prior to application submission to ensure the OPT application is submitted in a timely fashion to avoid a delayed start to the program should an offer be made. You can learn more about OPT requirements here.

If you have any questions regarding your eligibility for the program, you may contact SRF Director of Education Gregory Chin at [email protected].

Below is an alphabetical list of the Principal Investigators (PIs) and their 2019 Postbaccalaureate Fellowship research projects. Participating labs and specific research projects are similar but vary slightly from year to year. The 2020 Postbaccalaureate Fellowship research project options will be announced when the 2020 application period opens on November 1, 2019.

Principal Investigator: Julie Andersen, PhD

Buck Institute for Research on Aging

Neurofibrillary tangles are a defining hallmark of both Alzheimer’s and Parkinson’s disease and they or similar aggregates also appear in the neuronal cytoplasm in other neurodegenerative diseases of old age. One possibility for their formation is that these tangles arise from an autophagic “traffic jam” caused by lysosomal inactivation. Lysosomal autophagy is an important mechanism by which cells rid themselves of such proteotoxic aggregates. Restoration of lysosomal function therefore constitutes an attractive candidate target for these disorders. As part of funded research from the SENS Research Foundation, we have established human tau P30L mutant versus wildtype-expressing neurons as an in vitro model of disease to test whether restoration of lysosomal function can prevent or reverse the formation of toxic tau aggregates. We determined using this model that low-dose (0.1 microM) application of a pharmacological accelerator of autophagic flux, K604, decreases levels of phosphorylated tau and protects against neurite retraction associated with the P30L model, even following their formation. We now propose to use this model to test newly identified lysosomal rejuvenating factors recently identified by our laboratory as part of a compound library screen for such compounds. These could potentially serve as novel therapeutics for the treatment of Alzheimer’s and Parkinson’s disease.

Principal Investigator: Amutha Boominathan, PhD

SRF Research Center

Mitochondria are the power plants of the cell and are also the only cellular organelle that possess their own DNA in mammals. In humans, mitochondrial DNA (mtDNA) codes for 13 important proteins, which all assemble into the oxidative phosphorylation relay. Mutations in mtDNA occur as a consequence of constant exposure to reactive oxygen species produced by the mitochondrial energy generation process as well as mistakes in mtDNA replication. These mutations accumulate over time due to inefficient repair mechanisms and compromise respiratory chain function. Inherited and acquired mutations in mtDNA result in impaired energy generation and are the cause for several pathologies such as Leber’s hereditary optic neuropathy (LHON), Myoclonic Epilepsy with Ragged Red Fibers (MERRF), Kearns-Sayre syndrome and Leigh syndrome.

 

Using the allotopic approach, we have identified specific targeting elements/sequences that can improve expression of these essential genes from the nuclear DNA and their transport to the correct location in mitochondria. The Fellow selected will get the opportunity to design a library of constructs to attempt to rescue specific mtDNA mutations in model patient cell lines. The ability of re-engineered genes to rescue function will be evaluated through various techniques, such protein gels, qPCR and activity assays, with the potential of extending the studies to animal models. Time permitting, the Fellow will validate these constructs for expression from a safe harbor locus using the CRISPR/Cas9 and dual integrase mediated cassette exchange (DICE). Candidates with an interest in mitochondrial biology and with exposure to cell culture, molecular biology and protein biochemistry are encouraged to apply.

Principal Investigator: Lisa Ellerby, PhD

Buck Institute for Research on Aging

The potential project will involve modeling disease and aging in human induced pluripotent stem models. The Ellerby laboratory has established a number of disease models of Huntington’s disease, Parkinson’s disease and aging. We have developed different methods to identify novel therapeutic targets for HD and aging. The intern will generate models of disease and evaluate therapeutic targets to validate these for treatment of the disease.

Principal Investigator: Jeanne Loring, PhD

The Scripps Research Institute

The Loring lab is focused on harnessing the power of pluripotent stem cells for regenerative medicine. We believe that cells derived from pluripotent stem cells will revolutionize medicine and lead to longer and healthier lives. We are looking for an intern to work on our cell therapy project for Parkinson’s disease in which induced pluripotent stem cells from Parkinson’s patients are used to derive dopaminergic neurons, the same neurons which are lost in the brains of Parkinson’s patients. The aim of this Postbaccalaureate Fellow project is to evaluate whole-genome gene expression profiles from dopaminergic neurons derived from 10 different patient lines helping to build a model by which future cell lines can be evaluated prior to clinical use. The Fellow will generate the neurons from the patient stem cell lines and analyze the resulting gene expression data.

Principal Investigator: Matthew O’Connor, PhD

SRF Research Center

This research project is geared toward performing translational research studying aging as it relates to the immune system and senescent cells. More specifically, the Summer Scholar will study how the immune system interacts with senescent cells. Research will include testing of candidate signaling protein blockers to try to induce killing of senescent cells. Another aspect of this project will involve identifying and characterizing new types of senescent cells from among the many tissue and cell types in the body. This will involve high-throughput microscopy on our robotic microscope. The research project will be a collaborative effort between SRF and the Buck Institute for Research on Aging, located in Novato, CA.

Principal Investigator: Evan Snyder, MD, PhD

Sanford Consortium for Regenerative Medicine

We believe the study of stem cell biology will provide insights into many areas: developmental biology, homeostasis in the normal adult, and recovery from injury. Indeed, past and current research has already produced data in these areas that would have been difficult or impossible via any other vehicle. We have engaged in a multidisciplinary approach, simultaneously exploring the basic biology of stem cells, their role throughout the lifetime of an individual, as well as their therapeutic potential. Taken together, these bodies of knowledge will glean the greatest benefit for scientists and, most importantly, for patients. All of our research to date has been performed in animal models with the ultimate goal of bringing them to clinical trials as soon as possible.

 

Possible research project options include:

 

  1. Model Parkinson’s Disease (PD) using human induced pluripotent stem cells (hiPSCs)
  2. Search for molecules that confer a resistance to age-related degeneration
  3. What directs the homing of neural stem cells to areas of pathology?

Below is an alphabetical list of the Principal Investigators (PIs) and their 2020 Postbaccalaureate Fellowship research projects.

Principal Investigator: Julie Andersen, PhD

Buck Institute for Research on Aging

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Principal Investigator: Amutha Boominathan, PhD

SRF Research Center

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Principal Investigators: Martin Brand, PhD, and Amutha Boominathan, PhD

Buck Institute for Research on Aging

tbc

Principal Investigator: Lisa Ellerby, PhD

Buck Institute for Research on Aging

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Principal Investigator: Amit Sharma, PhD

SRF Research Center

tbc

Principal Investigator: Evan Snyder, MD, PhD

Sanford Consortium for Regenerative Medicine

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– The 2020 SRF Postbaccalaureate Fellowship Program application period will open on Friday, November 1, 2019. –

The application for the 2020 SRF Postbaccalaureate Fellowship Program is now available.

Applications will be accepted until noon PST Monday, February 17, 2020 (12pm PST 2/17/20). Please be sure to download the recommendation instructions and give your recommender(s) ample time to submit your letter of recommendation by the deadline.

Other SRF Education Opportunities

Summer Scholars Program

Offering undergraduate students the opportunity to conduct biomedical research to combat diseases of aging under the guidance of a scientific mentor and emphasizing the development of laboratory and communication skills to develop well-rounded future scientists.

Summer Scholars Program

Offering undergraduate students the opportunity to conduct biomedical research to combat diseases of aging under the guidance of a scientific mentor and emphasizing the development of laboratory and communication skills to develop well-rounded future scientists.

SRF Alliance

Funding PhD students at Oxford University in the field of healthcare translation to research international guidelines pertaining to digital health development and implementation, as well as healthcare regulation and standards world-wide.

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