On the Surface: a New Path to Finding and Clearing Aged Cells

The Problem Early studies show that destroying senescent, or old and dysfunctional, cells can delay or even reverse diseases of aging and extend lifespan. The primary strategy for turning this into a therapy has been “senolytic” drugs that target signaling pathways that senescent cells need for survival. The Goal An alternative approach, targeting senescent cells …

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A Better Way to Create Rejuvenation Therapies

The Problem IPF is linked to the accumulation of senescent, or old, cells in the lung, creating scar tissue (fibrosis) which progressively stiffens them. This disables the patient, eventually suffocating them within 2-4 years. IPF creates a high burden of senescent cells in the lungs, and removing senescent cells powerfully impacts the disease. Previous drug …

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Boosting Natural Defenses: Modifying Immune Cells to Target Senescence

The Problem The immune system, including natural killer cells (NK cells), has an ability to patrol for and destroy senescent, or aged cells. However, this protective function deteriorates over time, permitting senescent cells to accumulate in our tissues and drive age-related disease. Drugs used to destroy senescent cells – senolytics – use a brute-force method …

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