Exploring Synergies between Senolysis and Stem Cell Therapy

Research Info The accumulation of damaged/senescent cells in the body with time is a hall mark of aging. These cells are believed to play a key role in the onset and/or progression of various aging-associated diseases. More generally, the decreased regenerative ability of transplanted stem cells in older recipients may also be partly attributable to …

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Catalyzing Degradation of Tau Aggregates

Research Info Tau is the major microtubule-associated protein (MAP) in mature neurons in the central nervous system. The MAPT (microtubule-associated protein tau) gene encodes for six splice variants that are highly soluble; their main function is interacting and stabilizing microtubules, along with other MAPs. The ability of tau to stabilize the microtubule is aided by …

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Engineering Mitochondrial Genes into the Nucleus to Restore Mitochondrial Function

Research Info Mitochondria perform and support several vital functions in a cell, and the alternate genome, mtDNA, plays a critical role in organelle maintenance. There is increasing evidence that mitochondrial function declines with age, and that dysfunctional mitochondria adversely contribute to several metabolic and neuromuscular diseases. Our goal is to address age-acquired and inborn errors …

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Enhancing Innate Immune Surveillance of Senescent Cells

Research Info When normal cells lose their ability to replicate, they become senescent cells. Over time, senescent cells accumulate in aging tissues, spewing off a cocktail of inflammatory and growth factors, as well as enzymes that break down surrounding tissue and cause inflammation. This phenomenon is known as the “senescence-associated secretory phenotype” (SASP). Senescent cells – and …

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Identification and Targeting of Noncanonical Death Resistant Cells

SENS Research Foundation Research Center Forever Healthy Foundation Fellowship in Rejuvenation Biotechnology Fellow: Tesfahun Admasu When cells age, they lose their proliferative capacity and stop dividing in a phenomenon called senescence. Cellular senescence decreases the regenerative capacity of cells and tissues. Throughout the aging process, senescent cells accumulate and secrete a characteristic set of proteins, called …

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A Small Molecule Approach to Removal of Toxic Oxysterols as a Treatment For Atherosclerosis

This research program has successfully spun-out into a company! Visit the Cyclarity Therapeutics website for more information on their transformative approach to atherosclerosis. SENS Research Foundation Research Center Principal Investigator: Matthew O’ConnorResearch Team: Amelia Anderson, Carolyn Barnes, Angielyn Campo, Anne Corwin, Sirish Narayanan Many diseases of aging are driven in part by the accumulation of “junk inside …

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