Exploring Synergies between Senolysis and Stem Cell Therapy

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Research Info Team Members Photos Funding Research Info Team Members Publications Photos Funding The accumulation of damaged/senescent cells in the body with time is a hall mark of aging. These cells are believed to play a key role in the onset and/or progression of various aging-associated …

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Catalyzing Degradation of Tau Aggregates

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Research Info Team Members Publications Photos Funding Research Info Team Members Publications Photos Funding Tau is the major microtubule-associated protein (MAP) in mature neurons in the central nervous system. The MAPT (microtubule-associated protein tau) gene encodes for six splice variants that are highly soluble; their main …

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Engineering Mitochondrial Genes into the Nucleus to Restore Mitochondrial Function

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Research Info Team Members Publications Photos Funding Research Info Team Members Publications Photos Funding Mitochondria perform and support several vital functions in a cell, and the alternate genome, mtDNA, plays a critical role in organelle maintenance. There is increasing evidence that mitochondrial function declines with age, …

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Enhancing Innate Immune Surveillance of Senescent Cells

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Research Info Team Members Publications Resources Photos Funding Research Info Team Members Publications Resources Photos Funding When normal cells lose their ability to replicate, they become senescent cells. Over time, senescent cells accumulate in aging tissues, spewing off a cocktail of inflammatory and growth factors, as well as …

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Identification and Targeting of Noncanonical Death Resistant Cells

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS SENS Research Foundation Research Center Forever Healthy Foundation Fellowship in Rejuvenation Biotechnology Fellow: Tesfahun Admasu When cells age, they lose their proliferative capacity and stop dividing in a phenomenon called senescence. Cellular senescence decreases the regenerative capacity of cells and tissues. Throughout the aging process, senescent cells …

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A Small Molecule Approach to Removal of Toxic Oxysterols as a Treatment For Atherosclerosis

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This research program has successfully spun-out into a company! Visit the Cyclarity Therapeutics website for more information on their transformative approach to atherosclerosis. SENS Research Foundation Research Center Principal Investigator: Matthew O’ConnorResearch Team: Amelia Anderson, Carolyn Barnes, Angielyn Campo, Anne Corwin, Sirish Narayanan Many diseases of aging are …

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