Extramural Archives - SENS Research Foundation

Molecules to Destroy Microbial Invaders in the Brain and Hold Beta-Amyloid in Check

September 22, 2023September 5, 2023 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Stanford University Principal Investigator: Annelise E. BarronResearch Team: Kristian Sørensen, Jennifer Lin, Josefine Eilsø Nielsen, and John Fortkort The aging brain is vulnerable to invasion by infectious microbes, and there is compelling evidence that some of these pathogens drive neurodegenerative aging of the Alzheimer’s type (AD). …

Lipofuscin Degradation by Bacterial Hydrolases

September 5, 2023June 21, 2021 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS German Institute of Human Nutrition Principal Investigator: Tilman GruneResearch Team: Annett Braune, Annika Höhn, Tim Baldesperger Prof. Grune is the Scientific Director of the German Institute of Human Nutrition and has been working on protein degradation of damaged proteins and aging. Lipofuscin (LF) is a strongly …

Therapy to Destroy Cells with Reactivated “Jumping Genes”

May 26, 2022April 25, 2020 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Roswell Park Comprehensive Cancer Center Principal Investigator: Andrei GudkovResearch Team: Marina Antoch, Amy Stablewski, Nick Neznanov, Lilya Novototskaya, Olga Leontieva Nearly half of the mammalian genome is long and short interspersed virus-like repetitive elements (LINEs and SINEs), which spread through the process of retrotransposition. Numerous intracellular …

Functional Neuron Replacement to Rejuvenate the Neocortex

May 26, 2022March 25, 2019 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Albert Einstein College of Medicine Principal Investigator: Jean HébertResearch Team: Hiroko Nobuta, Joanna Krzyspiak, Alexandra Quezada, Marta Gronska-Peski, Jayleecia Smith Of all the challenges in cell therapy, replacement of neurons in the neocortex is both the most important (the brain being the seat of consciousness and identity) …

Glucosepane Crosslinks and Undoing Age-Related Tissue Damage

May 26, 2022March 25, 2019 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This research program has successfully spun-out into a company! Visit the Revel Pharmaceuticals website for more information on their transformative approach to tissue cross-linking and vascular disease. Yale University Principal Investigator: David SpiegelResearch Team: Prof. Jason Crawford, Nam Kim, Venkata Sabbasani, Matthew Streeter The long-lived collagen …

Maximally Modifiable Mouse

May 26, 2022March 25, 2019 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This project has recently concluded; further information will be published in the near future. Applied StemCell, Inc. Principal Investigator: Dr. Ruby Yanru Chen-Tsai The CRISPR/Cas9 gene editing system has the ability to make precisely-targeted changes in the genetic sequence – a clear strength of the platform …

Remediation of Aberrant Intracellular Tau

May 26, 2022March 25, 2019 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This project has recently concluded; further information will be published in the near future. Buck Institute for Research on Aging Principal Investigator: Dr. Julie AndersenResearch Team: Cyrene Arputhasamy, Manish Chamoli, Anand Rane Aging brains accumulate aggregates composed of aberrant forms of the protein tau, both inside …

Target Prioritization of Tissue Crosslinking

May 26, 2022March 25, 2019 by SRF

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS The Babraham Institute Principal Investigator: Jonathan ClarkResearch Team: Melanie Stammers As discussed in the project summary for “Glucosepane Crosslinks and Undoing Age-Related Tissue Damage”, adventitious crosslinking of collagen and elastin contributes to the slow stiffening of our arteries and other tissues with age. Some of these crosslinks …

About Us

Our Research

Education Opportunities

Get Involved

Receive our NewslEtter

Sign up to stay informed about the latest news and opportunities with SRF!

We respect your privacy. You can unsubscribe at any time.

Use of this Web site constitutes acceptance of the Terms of Use and Privacy Policy.

© 2023 SENS Research Foundation – ALL RIGHTS RESERVED

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.

Necessary

Always Enabled

Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.

Cookie	Duration	Description
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.