Molecules to Destroy Microbial Invaders in the Brain and Hold Beta-Amyloid in Check

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Stanford University Principal Investigator: Annelise E. BarronResearch Team: Kristian Sørensen, Jennifer Lin, Josefine Eilsø Nielsen, and John Fortkort The aging brain is vulnerable to invasion by infectious microbes, and there is compelling evidence that some of these pathogens drive neurodegenerative aging of the Alzheimer’s type (AD). …

Read more

Read more...

Lipofuscin Degradation by Bacterial Hydrolases

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS German Institute of Human Nutrition Principal Investigator: Tilman GruneResearch Team: Annett Braune, Annika Höhn, Tim Baldesperger Prof. Grune is the Scientific Director of the German Institute of Human Nutrition and has been working on protein degradation of damaged proteins and aging. Lipofuscin (LF) is a strongly …

Read more

Read more...

Therapy to Destroy Cells with Reactivated “Jumping Genes”

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Roswell Park Comprehensive Cancer Center Principal Investigator: Andrei GudkovResearch Team: Marina Antoch, Amy Stablewski, Nick Neznanov, Lilya Novototskaya, Olga Leontieva Nearly half of the mammalian genome is long and short interspersed virus-like repetitive elements (LINEs and SINEs), which spread through the process of retrotransposition. Numerous intracellular …

Read more

Read more...

Functional Neuron Replacement to Rejuvenate the Neocortex

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS Albert Einstein College of Medicine Principal Investigator: Jean HébertResearch Team: Hiroko Nobuta, Joanna Krzyspiak, Alexandra Quezada, Marta Gronska-Peski, Jayleecia Smith Of all the challenges in cell therapy, replacement of neurons in the neocortex is both the most important (the brain being the seat of consciousness and identity) …

Read more

Read more...

Glucosepane Crosslinks and Undoing Age-Related Tissue Damage

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This research program has successfully spun-out into a company! Visit the Revel Pharmaceuticals website for more information on their transformative approach to tissue cross-linking and vascular disease. Yale University Principal Investigator: David SpiegelResearch Team: Prof. Jason Crawford, Nam Kim, Venkata Sabbasani, Matthew Streeter The long-lived collagen …

Read more

Read more...

Maximally Modifiable Mouse

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This project has recently concluded; further information will be published in the near future. Applied StemCell, Inc. Principal Investigator: Dr. Ruby Yanru Chen-Tsai The CRISPR/Cas9 gene editing system has the ability to make precisely-targeted changes in the genetic sequence – a clear strength of the platform …

Read more

Read more...

Remediation of Aberrant Intracellular Tau

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS This project has recently concluded; further information will be published in the near future. Buck Institute for Research on Aging Principal Investigator: Dr. Julie AndersenResearch Team: Cyrene Arputhasamy, Manish Chamoli, Anand Rane Aging brains accumulate aggregates composed of aberrant forms of the protein tau, both inside …

Read more

Read more...

Target Prioritization of Tissue Crosslinking

Part of: AmyloSENS ApoptoSENS GlycoSENS LysoSENS MitoSENS OncoSENS RepleniSENS The Babraham Institute Principal Investigator: Jonathan ClarkResearch Team: Melanie Stammers As discussed in the project summary for “Glucosepane Crosslinks and Undoing Age-Related Tissue Damage”, adventitious crosslinking of collagen and elastin contributes to the slow stiffening of our arteries and other tissues with age. Some of these crosslinks …

Read more

Read more...

Use of this Web site constitutes acceptance of the Terms of Use and Privacy Policy.

© 2023 SENS Research Foundation – ALL RIGHTS RESERVED

Thank you for Subscribing to the SENS Research Foundation Newsletter.

You can also

or

You can