British Daily Mirror featured an interview with SENS Research Foundation’s Science Writer Michael Rae about the world’s richest men taking on the longevity challenge

As part of the widespread media coverage of the launch of Altos Labs and the rising tide of investment into rejuvenation biotechnology, a recent article in a British daily featured an interview with SENS Research Foundation’s Science Writer Michael Rae on Altos Labs, cellular reprogramming, and its place within the SENS platform of rejuvenation biotechnologies and the push toward a future of indefinite medical maintenance of healthy, youthful life.
Michael Rae-Wide

In the wake of the summer space race between Richard Branson, Jeff Bezos and Elon Musk, the world’s richest men are taking on a new challenge – immortality.

Amazon boss Bezos, 57, is one of the main backers of Altos Labs, which has raised £200million and just opened a new laboratory in Cambridge.

But Bezos, worth £150billion, is far from being the only one taking on the grim reaper.

Google co-founder Sergey Brin, 48, has invested more than £600million in a “longevity lab” called Calico.

Meanwhile Russian tech mogul Yuri Milner, 59 – worth around £3billion – has handed grants worth millions of pounds to the science of anti-ageing.

Longevity expert Michael Rae, 50, from California’s Bay Area, tells the Sunday People that the science of living forever is making huge leaps forward.

As well as being backed by Thiel, his SENS group has also had meetings with Bezos.

And with big-money backing, he is optimistic …

SENS Research Foundation, based in Mountain View, California, believes aging is a disease that can be tackled like any other.

Its goal is to “comprehensively repair the damage that builds up in our bodies over time.”

One research strand is asking if backup copies of cells [sic — mitochondrial DNA -SRF] can be created to replace malfunctioning ones.

The new cells [sic — mitochondrial DNA -SRF] would be implanted in our flesh so they can take over when our system starts to degrade.

This would mean we can refurbish our bodies time and again – like we replace faulty chips in a computer.

Michael Rae, 50, a science writer at the foundation, explains: “The Big Kahuna is when we get to the point that your life expectancy is no longer a function of your age.“

“Right now, every year you live, you’re closer to your doom. Once you take away ageing, it becomes open-ended. That doesn’t mean you’re immortal – you can still be murdered or hit by a catastrophic infection like Ebola, or die in a plane crash.“

“But you are no longer going to be more vulnerable to disease and death.“

“At that point, if you do the maths on how unlikely it is to die, it gives a life expectancy of about 1,000 years.

“You can still die the next day, or live to 2,000 years. It becomes about what happens in your life.” …

Longevity expert Michael Rae is hopeful that death from serious disease will plummet in the next decade as anti-ageing drugs currently in development hit the market.

He said: “One rejuvenation technology I suspect is going to be coming pretty quickly, in the next 10 years, is with drugs called senolytics.“

“There are certain cells that stop reproducing themselves and become metabolically abnormal.”

“They start excreting all kinds of inflammatory factors that make them more prone to becoming cancerous.“

“Senolytic drugs selectively kill those cells – there’s evidence that the body becomes rejuvenated in a wide variety of ways when you use them.“

“These drugs should be effective in eliminating a number of age-related diseases, which is a big step forward.“

“The immune system can already remove these damaged cells – but it seems it either falls apart as we age or it’s just incomplete.“

“We’re working on a range of ways to make it easier for your immune system to clear those cells out.“

“One thing we’re looking at to do this is by using engineered cells that will do the job for you.” …

He said: “The big concern I have about the research is that it’s not going fast enough because it’s not being funded adequately.“

“We’re not going half as fast as I’d like – every day that we’re delayed, we have another 110,000 people dead from this plague of ageing.“

“I watched my grandparents die. My grandfather was living on oxygen and had a hard time walking around by the time he passed.“

“My grandmother was almost blind and needed help getting out of bed.“

“I’ve done a variety of things to keep myself healthy, but I’m conscious the science is not developing as quickly as I would want.“

“Beyond that, yes there are concerns. If we unshackle people from the ageing process, the population is going to increase over time and that could pose certain ecological constraints.“

“It’s certainly going to pose a need for rethinking things like retirement ages and pension plans – and the way we structure our lives around ageing and dying.“

“But one has to maintain a sense of proportion. These things have technical fixes.“

“We have to be better about using resources on all kinds of fronts because the world is already headed for an environmental disaster.“

“Are we really saying the solution to things like our ecological problems is that people have to keep dying of cancer and heart attacks?”

Biological reprogramming technology

Amazon boss Jeff Bezos is reported to be one of the main backers of Altos Labs, a collection of state-of-the-art research centres in Cambridge, Japan and California headed by US scientist and cancer expert Richard Klausner.

The scientists here are using £200million of funding to develop something known as “biological reprogramming technology”.

This will allow the cells in our body to be rejuvenated, turning back the clock and reversing the ageing process.

There is also hope that the research will bring an end to life-changing conditions such as Parkinson’s, heart disease and cancer – as our cells will no longer degenerate and mutate.

One new scientist on the team, Spaniard Manuel Serrano, says he was offered five times his salary to move to Cambridge to work for Altos Labs, showing the firm is recruiting the best and brightest in the business.

Expert Michael Rae told us: “Reprogramming technology is taking a cell that has accumulated age-related changes that are dysfunctional and winding the clock back.

“You remove some of those abnormal changes, so it behaves like a youthful cell.

“Once you’ve done that it starts ageing again. So eventually you will have to wind it back again and again – but that’s fine as long as you keep up with it.

“In some ways that is even more exciting because if you are 70 years old and you can wind the clock back, you’ve done a lot for that person.

“Bezos is in his 50s – so he has made a bet that’s going to pay out at a very good time for him.”

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