The SENSible Blog discusses the development of rejuvenation biotechnology around the world: progress being made in the field of longevity, the design of medical therapies to cure, reverse and prevent the diseases and disabilities of aging, and much more.

Our content is a blend of popular interest articles – labelled “Easy Reads”, and designed to require no specific background knowledge – as well as more detailed scientific commentaries, labelled as “In-Depth” and aimed towards readers with some grounding in the biological/medical sciences.

Does An Immune Role for Beta- Amyloid Create a Therapeutic Dilemma for SENS?

Some scientists have reported that viruses, bacteria, and other pathogens may help drive Alzheimer’s and other neurodegenerative diseases, and that the body uses beta-amyloid protein to fight them off. That seems to imply that it’s a bad idea to remove Abeta from the brain. Here we explain how the SENS “damage-repair” strategy leaps over that therapeutic dilemma — just as it does with other kinds of aging damage.

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Easy Read

New Peer-Reviewed Paper from SENS Research Foundation Reports a Better Method to Study How Immune Cells Seek and Destroy Senescent Cells

We are proud to announce the recent publication by Sharma lab/ApoptoSENS team in the journal Aging describing an improved method for enriching primary NK cells from human peripheral blood and demonstrating the ability of those NK cells to eliminate senescent cells by recapitulating more physiological conditions and potential therapeutic interventions.

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Easy Read

Michael Rae and Dr. Robert Rodgers discuss Parkinson’s and aging

SENS Research Foundation’s science writer Michael Rae was interviewed on the Parkinson’s Recovery radio program on “The coming rejuvenation biotechnology revolution for Parkinson’s disease.” In it, they discussed how the cellular and molecular damage of aging most closely involved in Parkinson’s can be removed, replaced, or repaired using rejuvenation biotechnologies, and research underway to make it happen.Read more and listen to the interview to learn how a “damage-repair” approach can prevent, arrest, and eventually consign Parkinson’s to history.

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Easy Read

Hyperbolic Hyperbaric “Age Reversal”

Lower-quality, clickbait-hungry media outlets love sensationalist claims, but one does expect better from the public relations department of an internationally-respected research university. And it was an easy jump from the already-overstated “In First, Aging Stopped in Humans” and “treatments can reverse two processes associated with aging and its illnesses” to saying that a treatment “can reverse

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In-Depth

Parabiosis: the Dilution Solution?

In heterochronic parabiosis, joining the circulatory systems of young and old mice causes the older animal to recover some features of youth. The effect has been widely assumed to be driven by pro-youth factors in younger blood, but an alternative hypothesis is possible: that the procedure is instead diluting pro-aging factors in the older partner.

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