Job Opportunity: Laboratory Manager

Job Type: Full-time
Title: Laboratory Manager
Salary: Pay is salaried, commensurate with experience and local rates; typical range $55,000-60,000/year.

SENS Research Foundation (SRF) is hiring a Laboratory Manager for our research center located in Mountain View, Silicon Valley, CA. SRF is a non-profit organisation globally recognized for its dedication to transforming the way the world researches and treats aging (www.sens.org)

The research center hosts the SRF internal research and affiliated initiatives including SRF spinout Underdog Pharmaceuticals. Our ca. 20 lab members include postdoctoral specialists as well as student researchers. The Laboratory Manager will provide daily support, supervision and coordination at every level to ensure the smooth running of all laboratory research.

The ideal candidate is a person that loves an orderly lab and rises to the challenge of changing requirements of cutting edge science. You need to be able to work independently and set your own tasks and priorities but communicate consistently and effectively with all laboratory personnel, nurturing lab cohesiveness and team spirit.

KEY RESPONSIBILITIES:

  • organize and oversee the daily operation of the research lab
  • inventory management, ordering and purchasing of research consumables (including effective negotiations with suppliers and service providers)
  • conduct regular maintenance of equipment
  • oversee general adherence to good animal husbandry (rodents)
  • mentor and supervise new staff in standard laboratory procedures
  • maintain a clean, safe laboratory and hold people accountable
  • regular and project-specific reporting to the VP (research)
  • develop and implement appropriate administrative policies and procedures for the laboratory
  • as required by research leads from time to time: assist with experiments, data entry and analysis

QUALIFICATIONS: required

  • a first or advanced degree in Biology, Biochemistry, Chemistry or related field
  • 5+ years’ laboratory experience
  • experience in research-related supervision, training or teaching
  • good interpersonal, written and verbal communication skills
  • advanced familiarity with MS Excel and similar applications
  • ability to maintain complete and organized records/reports
  • proven ability to organise cost-effective procurement

QUALIFICATIONS: desirable

  • Experience running and maintaining HPLCs
  • Experience in running automated microscopy
  • Experience with animal (rodent) husbandry
  • Experience with flow cytometry
  • Experience in running cell culture
  • Experience with RT-PCR
  • Experience with lab procurement software (e.g. Quartzy)
  • Knowledge of aging biology

We offer an excellent benefits package including paid vacation and sick leave, fully covered health and dental insurance (inclusive of dependents), an FSA program, and a company matched 401(k) plan, all of which is offered after a 90-day introductory period. SENS Research Foundation is an equal opportunity employer. We may sponsor a visa for international applicants.

The position is available now and will be filled as soon as the qualified candidate is found.

TO APPLY:

Please submit your CV along with a Cover Letter to [email protected].

COVID-19 considerations:

All employees are to follow COVID restrictions, which will lighten as our workplace is vaccinated. All employees are expected to wear PPE. Vaccinating is strongly encouraged.

Michael Greve Doubles Down

Michael Greve, founder of the Forever Healthy Foundation and owner of Kizoo Technology Ventures, announced today that he will make an additional €300 million ($361m USD) available to launch new rejuvenation biotechnology startups and support the clinical translation of therapies designed by Kizoo’s existing portfolio of companies.

Read the full press release at Forever Healthy.

Defeating Aging by 2036

SRF’s Chief Science Officer, Dr. Aubrey de Grey, recently estimated a 50% chance that aging could be brought under medical control in as little as 15 years’ time. In a new interview with NextBigFuture, Dr. de Grey explains how recent developments – including the global response to the COVID-19 pandemic – contributed to that prediction.

Read the full interview write-up here: How the World Defeats Aging by 2036

SRF Masks Available

Official SRF Masks
Now Available

At the end of 2020, we invited all our supporters to submit designs for an official SRF mask. As well as being worn by our staff, these masks are now available – while supplies last – to anyone who’d like to support our work to end age-related disease and disability.

The Importance of Masks

It’s widely agreed that wearing a mask reduces your chances of transmitting SARS-CoV-2 to others, even during the critical period of “silent spread,” when you have no symptoms and are most likely to transmit the virus to your friends and neighbors.

There’s now a growing body of evidence that wearing a mask also protects you from becoming infected, as well as evidence (reviewed in a recent article from the New England Journal of Medicine) that individuals who get infected despite wearing a mask are still several times less likely to develop severe illness. This may be because face coverings significantly reduce the initial dose of the virus received, giving the body more time to mount a response before things get out of hand.

The Winning Design

The winning design features icons representing the seven strands of the SENS platform, each of which aims to repair a specific category of age-related damage and thus cure and prevent the chronic diseases that it drives. To learn more about the strands, visit the Intro to SENS Research page.

Technical Details

Mask is 100% cotton on the inside and polyester on the outside, has a pocket to fit a filter and has a nose clip. Washable and reusable. Size: 5.5″ x 8.7”

Filter is a 5 ply face mask insert which effectively protects against PM2.5 and other airborne contaminants. Featuring 5 layers of protection including 2 non woven fabric layers, 2 melt blown fabric layers and an activated carbon layer in the middle for max protection. These are disposable and should be replaced every 5 days or less of constant use. Size: 4.72” x 3.15”

Material: Non-Woven Fabric + Melt-Blown Fabric + Activated Carbon Fabric + Melt-Blown Fabric + Non-Woven Fabric

Mask Availability

If you’d like to secure an official SRF mask for yourself, you can order by making a donation through the PayPal links below.

WebMD Feature: Is There a Cure for Aging?

“I think there is at least a 50/50 chance that most people alive today will live to 1,000 years old.”

In a new video produced for WebMD.com, SRF Chief Science Officer Dr. Aubrey de Grey discusses emerging medical technologies that could not only pause aging, but reverse it, in the surprisingly near future.

The video above is included in WebMD.com’s feature article “Is There a Cure for Aging?“, which includes more quotes from Dr. de Grey and other longevity leaders. Check it out!

Enriching Mitochondria

The MitoSENS team has recently published a new protocol which enables researchers to isolate mitochondria from mammalian cells more efficiently and scalably than any prior technique, using only readily available and economical reagents and equipment.

The full text is available to read for free via MethodsX: Rapid enrichment of mitochondria from mammalian cell cultures using digitonin

Abstract

We describe here a simple method to enrich mitochondrial fractions from mammalian cells for downstream analyses in the lab. Mitochondria purification involves cell lysis followed by separation of the organelles from the rest of the cellular components. Here, we use detergent to rupture the cell membrane of mammalian cells followed by differential centrifugation to enrich the organelles. Optimum conditions with respect to detergent concentration, time, sample size, and yield are discussed. The method’s utility in downstream analyses and ease of processing multiple samples simultaneously is also described. All the reagents in this method can be assembled in-house, are economical, and are comparable, if not superior, to commercially available kits in terms of mitochondrial yield and integrity.

  • Rapid enrichment of mitochondria from mammalian cells using commonly available reagents.
  • Multiple samples can be processed simultaneously.
  • Works over a wide range of sample size (1 million to 100 million cells).

Graphical Abstract

Undoing Aging is rescheduled to May 26-28, 2022

Forever Healthy Foundation and  SENS Research Foundation have rescheduled Undoing Aging to 2022. We are looking forward to having Undoing Aging 2022 as a vibrant physical event in Berlin, which unfortunately is not possible in 2021 due to restrictions on events in Germany and the global Corona situation. We will issue ticket refunds to attendees who cannot attend the new date. It will take place May 26-28 at the Radialsystem Berlin. 

The Undoing Aging Conference is focused on the cellular and molecular repair of age-related damage as the basis of therapies to bring aging under full medical control and will bring together scientists and startups from around the globe, all pioneers in their respective fields, who are leading the charge in maintaining and restoring full health in old age.

To accommodate the exciting growth of the emerging rejuvenation biotechnology industry, Undoing Aging 2022 will add a dedicated forum and exhibition space for rejuvenation biotech companies to present themselves to prospective investors and industry partners.

Additionally, the 2022 conference will add a special “Rejuvenation Now” session highlighting the first generation of human rejuvenation therapies that are either currently in clinical trials or are available today.

Undoing Aging 2022 is not only open to the scientific community, but also welcomes startups, investors, the general media, and all interested members of the broader rejuvenation movement. The conference will feature a student poster session showing the work of innovative undergraduate and graduate students in the field of damage repair.

Scientific Organizer: Dr. Aubrey de Grey

Antonov Foundation donates $1M to SRF’s End of Year Campaign

At the end of each year, SRF launches our final fundraising campaign – the aptly named End of Year Campaign – to encourage our donors to donate during the most giving time of year. Most years we have good success in meeting our goal, in large part due to the multitude of donors who believe in our mission to end age-related disease.

2020 was a particularly difficult year for everyone. With the COVID-19 pandemic hitting across the globe, jobs being lost or postponed, families being separated, and loved ones dying, our foundation also took a hit. We struggled to find safe and effective ways to continue our life-saving research, both internally and externally. Our Education program suddenly had to find ways to host the students, or else close the program for this year. The enormously successful Undoing Aging Conference was postponed, then postponed again, as restrictions from various countries became more severe to battle the rise in infections.

This year, more than ever, our End of Year Campaign was vital to the survival of SENS Research Foundation and the work that we do to combat all causes of age-related disease and disability. This includes COVID-19, as the greatest predictor of death from this virus is age.

Despite all the challenges, a long-time supporter of ours came forward with a generous donation and a challenge to our base. 

Michael Antonov

The Michael Antonov Foundation was founded with a vision of extending average human lifespan to over 120 and enabling people to better understand the world and become masters of their own destiny. The foundation makes grants and gifts to 501(c)(3) organizations that perform human longevity-centered research and collaborates with industry players in order to maximize the impact of longevity-centered projects. Michael Antonov, the founder of the foundation, is a serial entrepreneur and philanthropist passionate about taking on a challenge to extend human lifespan and make them more meaningful. In addition to the foundation, Michael Antonov is the founder of Formic Ventures, an early stage longevity-focused venture capital firm and was previously the co-founder and Chief Software Architect at Oculus, where he helped revive the virtual reality industry.

Michael Antonov donated $400,000.00 to SRF outright at the beginning of our campaign, then set up a matching grant of up to $600,000.00 for our supporters to match. His generosity and vision for our cause encouraged eleven other supporters of SRF to turn his offer of doubling donations into a triple donation. The first $525,000.00 of support we received was tripled, and we are thrilled to announce that the full $600,000.00 of the original match was met. SRF raised a total of $2,335,443.46 in this year’s campaign.

Thank you, from all of us at SRF, for your ongoing support. It takes all of us strongly united as a community, to tackle the issues that we at SRF strive to solve. We would not be able to make the progress we do without the support of benefactors like Michael Antonov, and the dedication and generosity of every single donor, particularly during such trying times as we find ourselves currently.

Thank you again. SRF lives another day to #UnlockLongevity.

Catalysing ApoptoSENS

We are pleased to announce that the ApoptoSENS team led by Dr. Amit Sharma at the SRF Research Center has recently been granted a Catalyst award, courtesy of the Healthy Longevity Global Competition, to continue and expand their critical work on the interactions between senescent cells and natural killer (NK) cells.

The Healthy Longevity Global Competition, administered by the U.S. National Academy of Medicine (NAM) with support from Johnson & Johnson Innovation, will issue up to 24 Catalyst Awards per year between 2020 and 2022. Each Catalyst Award includes a $50,000 cash prize and travel costs to attend an annual Innovator Summit, beginning in summer 2021. The American Federation for Aging Research (AFAR) will collaborate with the NAM on the application and scientific review process.

The major consequence of unresolved DNA damage is a state of growth arrest termed cellular senescence. Although senescence can prevent mutated cells from transforming into cancer, it can also contribute to age-related disease – largely because senescent cells secrete pro-inflammatory factors, collectively known as the Senescence Associated Secretory Phenotype (SASP).

Strong correlations between the accumulation of senescent cells with increasing age and various negative outcomes, as well as the improvements in healthspan observed in several animal models upon their removal, have made senescent cells attractive targets for rejuvenation therapies. The ApoptoSENS strand of the SENS platform is dedicated to the development of those treatments.

Natural Killer (NK) cells are innate immune cells that surveil the body for precancerous cells and cells infected with viruses and other intracellular pathogens. Once the NK cells recognize a target (based on its display of activating and inhibitory receptors), they release cytotoxic proteins such as perforin and granzymes, which induce programmed death – apoptosis – in the target cells.

Recent reports indicate that NK cells can also selectively eliminate senescent cells in cell culture and animal models, opening up a new avenue to develop therapeutic interventions.

This field of research is still in its infancy, and there are several unanswered questions, such as:

  1. can senescent cells escape immune clearance by secreting or presenting decoy receptors, and
  2. how does immune senescence (NK cell aging) impact the cytotoxic potential of NK cells towards senescent cells?

Supported by the Catalyst Award, the ApoptoSENS team will now investigate whether the age-related loss of cytotoxic potential of NK cells toward senescent cells is reversible and, if so, whether and how this may provide routes for therapeutic intervention. If successful, this work will clear a major hurdle to realizing NK cell-based treatments for senescent cell elimination.

Use of this Web site constitutes acceptance of the Terms of Use and Privacy Policy.

© 2020 SENS Research Foundation – ALL RIGHTS RESERVED

Thank you for Subscribing to the SENS Research Foundation Newsletter.

You can also

or

You can