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ZBTB40 is a telomere-associated protein and protects telomeres in human ALT cells
Mingqing Zhou 1, Yinghong Cui 1, Shanru Zuo 1, Qiyao Peng 1, Yucong Liu 1, Xueguang Li 1, Yide Yang 1, Quanze He 2, Xing Yu 1, Junhua Zhou 1, Zuping He 3, Quanyuan He 4
...Here we demonstrated that ZBTB40 is a novel telomere-associated protein and binds to telomeric dsDNA through its N-terminal BTB domain in ALT cells. Notably, the knockout or knockdown of ZBTB40 resulted in the telomere dysfunction induced foci (TIF) and telomere lengthening in the ALT cells. The results also show that ZBTB40 is associated with ALT-associated promyelocytic leukemia (PML) nuclear bodies (APBs) and the loss of ZBTB40 induces the accumulation of the APBs in U2OS cells. Taken together, our results implicate that ZBTB40 is a key player of telomere protection and telomere lengthening regulation in human ALT cells.