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Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ
Xiao-Xi Pan 1, Kang-Li Yao 2, Yong-Feng Yang 3, Qian Ge 1, Run Zhang 2, Ping-Jin Gao 1, Cheng-Chao Ruan 3, Fang Wu 2
...Here, we compared the difference in morphology and function of adipose tissue between young (3-month-old) and old (18-month-old) mice and showed the phenomenon of brown adipose tissue (BAT) "whitening" in old mice. Flow cytometry analysis suggested an increased proportion of T cells in BAT of old mice comparing with the young and exhibited senescent characteristics. We take advantage of coculture system to demonstrate directly that senescent T cells inhibited brown adipocyte differentiation of preadipocytes in adipose tissue. Mechanistically, both in vitro and in vivo studies suggested that senescent T cells produced and released a higher level of IFN-γ, which plays a critical role in inhibition of preadipocyte-to-brown adipocyte differentiation. Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation.