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Reciprocal blood exchange in heterochronic parabionts has a deleterious effect on the lifespan of young animals without a positive effect for old animals
Iryna Pishel 1 2, Tatiana Yankova 3, Tatiana Dubiley 4, Dmytro Shytikov 5
Our previous study showed that the exchange of blood between heterochronic parabionts for 3 months did not rejuvenate the immune system of the old partners. Moreover, the young immune system became more aged and began to function according to the "old" principle. Does this "forced aging" affect all organism's systems in this model? We checked the levels of corticosterone, testosterone, IGF-1, insulin, thyroxine in the blood of heterochronic parabionts but did not find significant changes compared to the age-related controls. Since numerous data support the possibility of rejuvenation of the brain, muscles, and other tissues using the model of heterochronic parabiosis, as well as opposite data, we planned to assess the overall effect of this long-term blood exchange on the rate of organism aging. We measured the lifespan of animals that exchanged with blood for 3 months and then were disconnected. Median and maximum life expectancy decreased in young heterochronic parabionts compared with the isochronic control. Old heterochronic parabionts showed only a small trend towards an increase in the median lifespan but it was not statistically significant, and the maximum lifespan did not change compared to the isochronic parabionts. These data support our assumption that old blood contains factors capable of inducing aging in young animals. Finding and selective suppression of aging factor production in the organism could be the key research field for life extension.