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New intranasal and injectable gene therapy for healthy life extension
Dabbu Kumar Jaijyan 1, Anca Selariu 2, Ruth Cruz-Cosme 3, Mingming Tong 4, Shaomin Yang 5, Alketa Stefa 1 6, David Kekich 2, Junichi Sadoshima 4, Utz Herbig 1 6, Qiyi Tang 3, George Church 7, Elizabeth L Parrish 2, Hua Zhu 1
Using CMV as a gene therapy vector we illustrated that CMV can be used therapeutically as a monthly inhaled or intraperitoneally delivered treatment for aging-associated decline. Exogenous telomerase reverse transcriptase or follistatin genes were safely and effectively delivered in a murine model. This treatment significantly improved biomarkers associated with healthy aging, and the mouse lifespan was increased up to 41% without an increased risk of cancer...