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Exercise reduces circulating biomarkers of cellular senescence in humans
Davis A Englund 1 2, Ayumi E Sakamoto 1 2, Chad M Fritsche 3, Amanda A Heeren 1 2, Xu Zhang 1, Brian R Kotajarvi 4, Denise R Lecy 3, Matthew J Yousefzadeh 5, Marissa J Schafer 1 6, Thomas A White 1 2, Elizabeth J Atkinson 7, Nathan K LeBrasseur 1 2 6
...Here, we report that a 12-week structured exercise program drives significant improvements in several performance-based and self-reported measures of physical function in older adults. Impressively, the expression of key markers of the senescence program, including p16, p21, cGAS, and TNFα, were significantly lowered in CD3+ T cells in response to the intervention, as were the circulating concentrations of multiple senescence-related proteins. Moreover, partial least squares discriminant analysis showed levels of senescence-related proteins at baseline were predictive of changes in physical function in response to the exercise intervention. Our study provides first-in-human evidence that biomarkers of senescent cell burden are significantly lowered by a structured exercise program and predictive of the adaptive response to exercise.