SENS PubMed Publication Search
Cellular senescence: when growth stimulation meets cell cycle arrest
Mikhail V Blagosklonny 1
At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.