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Biological age is increased by stress and restored upon recovery
Jesse R Poganik 1, Bohan Zhang 1, Gurpreet S Baht 2, Alexander Tyshkovskiy 1, Amy Deik 3, Csaba Kerepesi 4, Sun Hee Yim 1, Ake T Lu 5, Amin Haghani 5, Tong Gong 6, Anna M Hedman 6, Ellika Andolf 7, Göran Pershagen 8, Catarina Almqvist 9, Clary B Clish 3, Steve Horvath 10, James P White 11, Vadim N Gladyshev 12
...Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.