SENS PubMed Publication Search
Ageing of the B-cell repertoire.
Martin V, Bryan Wu YC, Kipling D, Dunn-Walters D
.....In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.