Dear SRF supporters,
Thank you for helping us build a future free of age-related disease through your generous support.
2021 brought unprecedented challenges to SRF, individually and as an organization. In the face of struggles, we remain strong and united as a team, and our dedication to a future beyond the diseases and debility of aging remains our unwavering North Star. All of us at SRF are unwaveringly committed to continue advancing our mission as originally conceived by our visionary and pioneering founders.
We’re grateful to all of you for making this work possible: to the many donors whose commitment to our work has endured through all these years; to those who have become SRF Patrons by pledging to support us with recurring donations; and to the new donors who have joined our cause only recently.
We appreciate you more than words can say. We know you share our vision and passion for extending healthy lifespans, and you are the very building blocks upon whose foundation we all stand.
At SENS Research Foundation, we develop rejuvenation biotechnologies: new therapies that repair the cellular and molecular damage that accumulates in our tissues over time. By removing and repairing this damage, we will restore youthful health and function to aging people.
With your generous support, we are diligently working on critical research on a novel way to remove abnormally aggregated tau, which accumulates in our neurons with age and drives age-related cognitive decline and dementia. Our new approach offers the most promising potential solution to this challenging target, which is needed to help prevent, arrest, and even reverse the terrible loss of mind and personhood brought by Alzheimer’s disease and other neurological diseases of aging.
We are making the first progress in decades toward engineering “backup copies” of mitochondrial genes into our cells, which will preserve their function over time. By keeping our cellular “power plants” burning brightly, we could counteract age-related loss of tissue function to help prevent and reverse diseases of aging like Alzheimer’s, Parkinson’s and age-related muscle wasting (sarcopenia). And for the very first time, this process has been applied in a mouse that contains a backup copy for one of the genes in the nucleus from birth — and the mice are perfectly healthy and now close to 12 months old. We hope to publish our “MitoMice” results soon.
Your support is also enabling our exciting work on enhancing immune surveillance of senescent cells, which holds the potential to restore or fortify our bodies’ natural ability to eliminate these “undead” cells, which drive aging and tissue dysfunction through a toxic brew of factors known as the “senescence-associated secretory phenotype” (SASP).
Funding from our supporters has equipped our scientists with new tools. We’ve been able to acquire an Agilent xCELLigence System, a powerful microelectronic biosensor system that will allow our scientists to monitor cells in real time. The xCELLigence system makes it possible for our scientists to directly visualize the interaction between NK cells and senescent cells in real time, without the need for laborious processing. A new Nikon ECLIPSE Ti2E precision inverted microscope system allows us to image live cells and distinguish subcellular structures, such as monitoring the interactions of donor and recipient-cell mitochondria in mitochondrial transplantation experiments.
These are only a few highlights out of the many projects being conducted in our Mountain View Research Center. Beyond the work our scientists carry out in-house, your donations enable us to fund critical longevity therapeutics research in outside institutions, including: an ingenious new solution to sustaining ongoing replacement of damaged or dying neurons in the brain; identifying new enzymes to remove the hodge-podge of damaged cellular components known as lipofuscin from our cells; destroy cells with reactivated “jumping genes,” which drive inflammation and mutations in aging cells; and more.
From our founding, one of SRF’s main goals has been to help build a rejuvenation biotechnology industry, and today we see this becoming a reality more than ever. Our work is at the coalface, driving the early-stage and pioneering discoveries on which venture capital relies to create new biotech startups but for which venture capital has no incentive to fund, creating the beginning of the pipeline that ends with working therapies to make aging people young. From that early-stage work has sprung many new start-ups, grounded in our science and more widely on the “damage-repair” approach originally pioneered by SRF.
SENS Research Foundation is a public non-profit organization, and all the progress that we have made to date has been thanks to your help. For that, we are grateful — as will be those in the coming decades whose health and lives you sustain through the rejuvenation biotechnologies that you help us create.
Help us develop a new medicine that repairs the damage of aging, allowing us all to live lives of unprecedented longevity in youthful health and vigor.
With your support, we can build this together — for ourselves, for our loved ones, and for all the generations to come.
There are a wide range of ways to donate in support of our work:
Make a one-off donation, or become an SRF Patron by setting up a regular subscription, using the Paypal buttons on our Donation Page.
PayPal accepts most currencies, and you don’t need to create a PayPal account to make a one-off donation by credit or debit card.
Please post checks to:
Donating appreciated securities can reduce your capital gains and income tax liabilities.
Here is the form to provide your stock broker for donating stock.
Here’s a list of 9 major cryptocurrencies SRF accepts. For a full list of accepted cryptocurrencies please visit our DONATE page. Provide proof of your donation and we will send you a donation receipt for USA tax deduction.
By nominating SRF as your charity when you list an item on eBay, you can donate a percentage of your sales to us and benefit from reduced fees.
Add our eBay for Charity Page as a favourite to make it even easier!
Create a fundraiser for SRF on your own Facebook page! All proceeds come to SRF at the end of your fundraiser.
Facebook supports many countries world-wide: Austria, Australia, Belgium, Bulgaria, Canada, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Latvia, Lithuania, Luxembourg, Malta, Netherlands, New Zealand, Norway, Philippines, Poland, Portugal, Romania, Slovakia, Slovenia, South Africa, South Korea, Republic of Cyprus, Spain, Sweden, Switzerland, United Kingdom, and United States.
Donors in the UK can make a tax-exempt donation directly to our sister organization, SENS Foundation Europe.
For more information, contact Darren Reynolds.