Trans blood-brain barrier exosomes - Matthew Wood
Author: M.J.A. Wood - Department of Physiology, Anatomy and Genetics, University of Oxford
Successful delivery of macromolecular therapeutic agents across the blood brain barrier (BBB) to the central nervous system is a major challenge in the treatment of neurological diseases of aging. Recently, the exploitation of natural nanoparticles known as exosomes has been pioneered and demonstrates their potential as therapeutic delivery vehicles. The natural macromolecular delivery and targeting properties of exosomes are well exemplified with siRNA delivery systemically to brain to target genes implicated in Alzheimer's disease. Moreover, delivery of exosomes appears to be well tolerated. This novel natural nanotechnology therefore has potential for systemic drug delivery across the BBB to treat a range of neurological and neurodegenerative conditions.