MitoSENS - Preventing Mitochondrial Aging
Actor Edward James Olmos narrates this short introduction to the mitochondria, the tiny organelles that ‘burn’ oxygen and nutrients to power our cells, before considering how during aging that same process can damage mitochondrial DNA – eventually causing the host cell to go into decline. Mitochondrial mutations are strongly implicated in several age-related conditions including Parkinson’s disease and “sarcopenia”, the gradual loss of muscle experienced even by active seniors. SENS Research Foundation is developing a therapy to prevent the failure of all such cells by placing backup copies of key mitochondrial genes in the cell’s nucleus, where they are much better protected. With such a backup in place, damage to the mitochondrial DNA becomes irrelevant, and the cell can return to normal healthy function.