Mitochondrial-Derived Peptides and their Roles in Aging and Related Diseases
Pinchas Cohen, William and Sylvia Kugel Dean in Gerontology, USC Davis School of Gerontology; Executive Director, Ethel Percy Andrus Gerontology Center
The opening keynote address of Rejuvenation Biotechnology 2016 was delivered by Pinchas Cohen, William and Sylvia Kugel Dean in Gerontology at USC Davis School of Gerontology and Executive Director of the Ethel Percy Andrus Gerontology Center. Dr. Cohen's talk explored the new field of short mitochondrial-derived peptides, exemplified by humanin, which have been characterised by his lab and others over the last decade. Remarkably, these peptides have roles not just in regulating mitochondrial function but in a broad range of aging-related processes ranging from the metabolic syndrome to cancer, while their abundance within the body correlates strongly with lifespan and health outcomes.