Large life extension in mice using transdermal delivery of an aspirin pro-drug - Chongxi Yu

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Author: C. Yu - Techfields Pharma

The Aspirin pro-drug aspirinamine penetrates skin, blood-brain, blood-milk, and other membrane barriers thousands of times faster than aspirin. Aspirinamine has shown a very strong anti-diabetic (both type I and type II) activity in NOD and STZ mouse models, and exerts neuroprotective effects after stroke.

It increased the maximal life span of C57BL/6 mice by 26% (at dose of 15mg/kg, equal to 10mg/kg of aspirin) and 27% (at dose of 45mg/kg, equal to 30mg/kg of aspirin).