Introductory Scientific Animations

SENS Research Foundation has commissioned a series of 8 world-class animations, narrated by actor Edward James Olmos, to help explain how accumulated damage results in aging-related diseases such as heart disease and cancer. These videos offer a dynamic visual representation of the different categories of damage and demonstrate how we can combat age-associated illness by preventing or repairing the molecular and cellular damage that would otherwise lead to pathology.

Introduction to the SENS damage repair model

The metabolic processes that keep us alive are tremendously complex, as are the diseases which plague us in old age. Is there a simpler target for medicine?

AmyloSENS - Dissolving the Plaques

Clumps of worn-out proteins called amyloids build up between cells as we age, leading to diseases like Alzheimer's. What can we do about them?

ApoptoSENS - Clearing Senescent Cells

Our bodies constantly recycle failing cells and replace them with new, healthy ones. What happens when a cell won't die on schedule?

GlycoSENS - Breaking Sticky Bonds

Our blood transports sugar throughout the body to fuel every one of our cells. When that sugar sticks to the blood vessel walls, they can become dangerously stiff. Can we find a way to remove it?

LysoSENS - Reversing Heart Disease

Specialised cells in the blood collect and recycle the body's waste products. So why does old cholesterol still build up in aging arteries - and can we stop it?

MitoSENS - Preventing Mitochondrial Aging

Mitochondria provide energy for all our cells but, while doing so, can damage their own DNA and become toxic. How can we prevent this?

OncoSENS - Stopping Cancer at the Starting Line

One of our strongest natural defences against cancer is the gradual shortening of telomeres every time a cell divides. Can we stop cancer finding a way around that safeguard?

RepleniSENS - Replacing Lost Tissues

Although most dying cells are immediately replaced, that process becomes ever less effective as we age. Can we help the body to make up the difference?