Inducing exocytosis to remove lipofuscin - John Furber
In old age, redox-toxic lipofuscin clogs lysosomes in critical non-dividing cells. This blocks autophagy and cell maintenance, impairs cell functions, and can kill essential cells. Inducing exocytosis of lysosomes could clear toxic lipofuscin out of the cell, allowing autophagy and cell repair to restore the cell to a more youthful, healthy state. Induction of lysosomal exocytosis has been demonstrated in human cells. The signaling pathways are being mapped. We are testing methods to safely induce exocytosis of lipofuscin-loaded lysosomes in old cells.