Healthy aging: how to stay bonny & transcend inflammation? - Patrizia d'Alessio

Video Overview

Introduction           People are driven by their obsession to stay young, and most importantly, in a visible way. Promising healthy aging, the market of dietary supplements is growing. Inflammation is a strategic key element in major degenerative diseases and has stimulated research on “inflammaging”. It is also recognized that inflammation contributes to depression. How can inflammation be managed without treating it with anti-inflammatory drugs? Pro- or prebiotics have been shown to directly influence the microbioma, while natural compounds may reduce the symptoms of gut inflammation. To avoid gut colitis, various herbal remedies have been reviewed by S. Danese (Gut, 2011). Also, the buccal area and its specific microbiota considerably influence the global status of the digestive system and thus of the whole organism (N. Illuzzi). Moreover, on the base of stool analyses available now ( pharmacogenetics is increasingly entering the field of nutrition, aiming at the prediction and optimization of individual profiles of gut microbiome and immune-inflammatory-clinical responses to therapy. Nutrigenetics may have even greater potential. In many cases, modulating cytokine responses and changing the gut microbiota can be obtained by an elemental diet

Material and methods     Analyses correlating dietary intake with systemic markers of inflammation as high-sensitivity C-reactive protein (HS-CRP), Interleukin-6 (IL-6), and Tumor Necrosis Factor alpha (TNF-α) have been performed by us in the Ristomed study ( The multi-centric Ristomed study (PRIME and concentrated on healthy subjects in the range of 65-85 years. The tri-terpene tripterine, a chemical compound of Tripterygium woolfordii hoek a Chinese plant eaten in the soup, displays anti-inflammatory properties and prevents arthritis.

Results       Monoterpens of herbal origin (as identified by AISA Therapeutics) turned out to modulate the expression of Il-6 and improve mood. Results on hand grip improvement were correlated with anti-depressive effects of AISA 5203-L (Prime).

Conclusions          It seems that inflammation so heavily involved in aging progress and mood change can be best managed acting on diet because of the consequences of the microbiome stabilization. Supplementation by specific herbal compounds characterized for focused action on inflammatory markers and / or signaling, may enhance this anti-inflammatory properties of a diet.


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d’Alessio P. et al. Gender differences in response to dietary supplementation by Orange Peel Extract in elderly people in the Ristomed study: impact on Quality of Life and inflammation. Prime 2012; 2:30-7.

d’Alessio P. et al. Oral administration of d-Limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans.  Life Sciences, Vol. 92, 24–26, 10 July 2013, 1151–1156.