Dietary and Nutritional Manipulation of the Nuclear Transcription Factors, PPAR's and SREBP's, as a Tool for Reversing the Primary Diseases of Premature Death and Aging - Karen Kurtak
2.1 billion years of evolution has equipped us with a biochemical pathway that has the power to arrest, and in some cases reverse, the primary disease etiologies of aging and premature death in the developed world. Activation of the PPAR pathway arrests inflammatory signaling throughout the body, reverses damage to tissues, reverses insulin resistance and can even dissolve beta-amyloid plaque in the brain. It has played a critical role in the evolution of the metazoans and the successful migration of humans to all corners of the Earth. For two decades, various pharmaceuticals have been designed to activate the PPAR pathway but have consistently fallen short of expectations. There is nothing wrong with these drugs. The problem has been the standard "healthy" diet creating mixed signals that render the drugs ineffective. This talk explores the ongoing dance between the two primary nuclear receptors that mediate gene regulation of fatty acids. It discusses their interaction with sirtuins and telomerase, optimization of their obligate heterodimers, and why manipulation of dietary and nutritional factors are the most effective means of activation. These are effective tools that can be implemented NOW to slow, and in some cases reverse, the diseases of aging.