Catalytic Antibodies and Extracellular Aggregates - Dr. Sudhir Paul

Video Overview

In this lecture, Dr. Sudhir Paul from the University of Texas Medical School at Houston discusses the diverse diseases and problems that arise from protein misfolding, in particular the amyloid overproduction that leads to the brain plaques associated with Alzheimer's Disease. He explains why past clinical trials for vaccination have had detrimental side effects and summarizes the immunotherapeutic approach of the future: increasing the potency of catalytic antibodies to clear amyloid. Finally, he describes two specific problematic proteins and hints at early progress aimed at cleaving them.