Personal Information

Occupation

Research Scientist at the SENS RC

Biography

Dr. Matthew O'Connor was awarded his Master's degree at Northwestern Medical in 1999 for his work studying behavioral neuroscience in aged rodents. In 2005, at Baylor College of Medicine he received a PhD in Biochemistry for his work on proteins that regulate human telomeres. Postdoctoral research includes work at UC Berkeley on muscle stem cells and aging. In 2010, Dr. O'Connor joined the SENS Foundation and heads up the MitoSENS project at the research center in Mountain View, California. His research is focused on "allotopic expression" of mitochondrial genes where his team is engineering mitochondrial genes to be expressed from the nucleus and targeted to the mitochondia. Dr. O'Connor is passionate about performing basic research to combat the diseases and disabilities of aging.

Demographics

Real Name

Matthew O'Connor

Gender

Male

Location

Mountain View, Ca

Contact Details

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History

Member for

1 year 33 weeks

Related content

Publication

• Differentiation rather than aging of muscle stem cells abolishes their telomerase activity.
• Notch signaling pathway and tissue engineering.
• TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
• A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
• The human Rap1 protein complex and modulation of telomere length.
• Telosome -- A mammalian telomere associated complex formed by multiple telomeric proteins.
• PTOP interacts with POT1 and regulates its localization to telomeres.
• Aging-related alterations in the distribution of Ca(2+)-dependent PKC isoforms in rabbit hippocampus.
• Trace eyeblink conditioning in the freely moving rat: optimizing the conditioning parameters.