Along with mutations in our cellular DNA, some cells also suffer "epimutations:" permanent damage to the structures that control the expression of the underlying genes. SENS Foundation has identified biomedical strategies to keep the body healthy and functioning normally despite the low level of mutations that accumulate with age; the same strategies will also work for epimutations, if their rate of accumulation is similarly low. To give the first assurance that the rate of epimutation-hampered cell accumulation over the adult lifespan is low enough for the strategy to be comprehensive, SENS Foundation is funding research at Albert Einstein College of Medicine to put new methods to use in determining that rate more definitively.

Along with mutations in our chromosomes, aging bodies also accumulate disabling "deletion" mutations in the separate DNA housed in the energy-producing mitochondria. SENS Foundation has identified the placement of functioning "backup copies" of mitochondrial genes in the cell nucleus as an "engineering" solution to preempt the metabolic mayhem these mutations ultimately create. The Foundation is now funding the expansion of work in the lab of Dr. Marisol Corral-Debrinski at the Institut de la Vision at Pierre and Marie Curie University, Paris, who has developed the most promising method to achieve this goal for most, if not all, of the relevant mitochondrial genes.