Principal Investigators
PhD, George R. Brown Professor of Engineering, Rice University
Dr Alvarez is a P.E., a Diplomate of the American Academy of Environmental Engineers and a Fellow of ASCE. Honors include Past President of the Association of Environmental Engineering and Science Professors (AEESP); a Career Award from the National Science Foundation; and the Outstanding Achievement Award in Environmental Engineering from the University of Michigan.
MD, PhD, Chair, Department of Immunobiology and Co-director, Center on Aging, University of Arizona
Formerly professor of molecular microbiology and immunology at the Oregon Health Sciences University School of Medicine, Dr Nikolich-Zugich is an internationally noted expert on the immune system and age-related disorders, and leads the Biology of Aging Research Program at the Center, which addresses aging and age-related diseases such as inflammation, osteoporosis, infectious diseases, diabetes, cancer, dementias and sarcopenia (muscle loss associated with aging).
PhD, Chair, Department of Genetics, Albert Einstein College of Medicine
Formerly Director of the Buck Institute for Aging Research, Dr Vijg has been an Ellison Medical Foundation Senior Scholar, holds eight patents in research processes and methodologies, and collaborated in the development of the MutaMouse, the first transgenic model system for the in vivo quantification of somatic mutations in the laboratory mouse.
PhD, Research Director, Fondation Voir et Entendre, Institut de la Vision, Universite Pierre et Marie Curie
Marisol Corral-Debrinski, PhD. leads a research team at the newly opened Fondation Voir et Entendre in Paris, studying the role of mitochondria in diseases of the retina. Dr Corral-Debrinski has published a series of papers on allotopic expression, including the initial demonstration of the significance of mRNA targeting in mitochondrial protein expression; the extension of this work to human cells, the successful allotopic expression of the ATP6 gene, and most recently the actual rescue of cells with mitochondrial DNA mutations by allotopic expression of the corresponding proteins.
PhD, Director of the Chemical Immunology Research Center, University of Texas Medical School
Dr Paul discovered and studies antibodies able to mediate the catalytic cleavage of specific polypeptides, including endogenous proteins such as amyloid-beta. His anti-amyloid antibodies are able to achieve considerable plaque clearance in mouse models and are entering clinical development. Dr Paul's research also explores the application of catalytic antibodies to viral diseases including HIV, HCV, and Staphylococcus aureus.
