To date, three of the thirteen OXPHOS genes still encoded in the mitochondria have been allotopically expressed (AE) in human cells with mutated versions of the same gene, thereby rescuing a respiratory defect. Now we have the first report of a new gene, COX2, being allotopically expressed in yeast, by mutating the gene to overcome the hydrophobicity of the mitochondrial membrane; a similar mutation has been shown to underlie the ability of the unusual case of the soybean COX2, which is a case of a native nuclear-encoded COX2 gene.
SENS researchers have recently begun efforts to improve the effectiveness of the A2E degrading enzyme versatile peroxidase by developing a chimeric enzyme which also features an additional portion who is expected to be able to dramatically increase its activity. This project is currently in progress at the SENS Foundation research center in collaboration with the State University of New York at Plattsburgh.
It was early 2005 when I first read about SENS. I had already applied to several graduate schools at that time and was waiting to hear back, but as I delved into that article in Popular Science I knew this was something I wanted to be involved in. A lot of people were studying aging, but no one had a plan like this. I emailed Aubrey and it wasn't long before I was headed to Rice University in Houston; first to perform some preliminary research into the LysoSENS project, and then to begin a PhD studying microbial oxysterol degradation.
Intravenously delivered immunoglobulin G (IVIgG) is a mixture of antibodies extracted from human blood which has demonstrated promising preliminary results in clearing the beta-amyloid (Abeta) deposits that drive the pathogenesis of Alzheimer's disease. A recent study compares multiple commercial sources of IVIgG and finds significant differences in their Abeta-binding activity, suggesting that results from impending clinical trials are likely to be highly dependent on the specific "brand" of IVIgG in use.