Aubrey de Grey's publications

You can now order my book at Amazon:

de Grey ADNJ, Rae M. Ending Aging: The rejuvenation breakthroughs that could reverse human aging in our lifetime. New York, NY: St. Martin's Press, 2007, 416pp, hardcover (ISBN 0-312-36706-6)

This book is aimed at a broad audience, but it does so without dumbing down the science at all. As such, it is the ideal resource for either the biologist or the non-biologist, whether encountering SENS for the first time or wishing to absorb more of its details. And best of all, the Methuselah Foundation will receive all the royalties, which will go directly to funding the essential research required to make SENS a reality. Get thee hence.

Most of the following publications are provided here as PDFs of preprints; where that has not been possible there are links to abstracts. Reprints are available on request.

Introductions for the non-specialist
Overviews of the science underlying SENS
Social and ethical context of SENS, including within biogerontology
Obviation of mitochondrial mutations
Removal of lysosomal aggregates
A real cure for cancer, and why other nuclear mutations probably don't matter
Removing extracellular crosslinks and aggregates and unwanted cells
Mitochondrial mutations and their effects
Other

Introductions for the non-specialist:

de Grey ADNJ. An engineer's approach to the development of real anti-aging medicine. Science's SAGE KE 2003; 2003(1):vp1. Also in: The Fountain of Youth: Ethical, Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock, eds.), Oxford University Press, 2003, pp. 249-267.     PDF

de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biol 2004; 2(6):723-726.    PDF

de Grey ADNJ. The foreseeability of real anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7 (R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp. 59-68.    PDF

de Grey ADNJ. A strategy for postponing aging indefinitely. Studies in Health Technology and Informatics 2005; 118:209-219.    PDF

de Grey ADNJ. Aging, elimination of. Entry for inclusion in the Berkshire Encyclopedia of the 21st Century, 2008, in press.    PDF

Most of my publications are written for a specialist audience of biogerontologists or other biologists, but the ones above are intended for a more general audience. Start with them if you're new to the field, and especially if you aren't a biologist.

Overviews of the science underlying SENS:

de Grey ADNJ, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJM, Stock G. Time to talk SENS: critiquing the immutability of human aging. In: Increasing Healthy Life Span: Conventional Measures and Slowing the Innate Aging Process - Ninth Congress of the International Association of Biomedical Gerontology (D. Harman, ed.), Annals NY Acad Sci 2002; 959:452-462.    PDF

de Grey ADNJ. An engineer's approach to the development of real anti-aging medicine. Science's SAGE KE 2003; 2003(1):vp1. Also in: The Fountain of Youth: Ethical, Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock, eds.), Oxford University Press, 2004, pp. 249-267.     PDF

de Grey ADNJ. Challenging but essential targets for genuine anti-ageing drugs. Expert Opinion on Therapeutic Targets 2003; 7(1):1-5.    PDF

de Grey ADNJ. UK research on the biology of aging -- the next ten years. Lifespan 2003; 11(1):1-4.     PDF

de Grey ADNJ. Foreseeable and more distant rejuvenation therapies. In: Aging Interventions and Therapies (S.I.S. Rattan, ed.), World Scientific, 2005, pp. 379-395.     PDF

de Grey ADNJ. The foreseeability of real anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7 (R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp. 59-68.     PDF

de Grey ADNJ. A strategy for postponing aging indefinitely. Studies in Health Technology and Informatics 2005; 118:209-219.    PDF

de Grey ADNJ. Like it or not, life extension research extends beyond biogerontology. EMBO Reports 2005; 6(11):1000.    PDF

de Grey ADNJ. Strategie per un invecchiamento transcurabile ingegnerizzato. In: Alterando il destino dell'umanità (P. Donghi, ed.), Proceedings of the 2005 Spoletoscienza conference. Rome: Laterza & Figli, 2006, pp. 49-63. Translation by Bruna Tortorella.     PDF (in English)

de Grey ADNJ. Defeat of aging - utopia or foreseeable scientific reality? In: The Future of Life and the Future of our Civilization (V. Burdyuzha, ed.), Springer, 2006, pp. 277-290.    PDF

de Grey ADNJ. SENS is hard, yes, but not too hard to try: a reply to Warner. Rejuvenation Res 2006;9(4):443-445.    PDF

de Grey ADNJ. Living to 100 and maybe much longer: the engineering and biotechnology of life-extension medicine and when it may arrive. In: Proceedings of the 6th International Conference on Intelligent Processing and Manufacturing of Materials (J.A. Meech, ed.), 2008, in press.    PDF

de Grey ADNJ. Aging, elimination of. Entry for inclusion in the Berkshire Encyclopedia of the 21st Century, 2008, in press.    PDF

de Grey ADNJ. Man, machines, manufacturing and maintenance: merits of a much-maligned metaphor. Rejuvenation Res 2008; 11(2):277-279.    PDF

Social and ethical context of SENS, including within biogerontology:

de Grey ADNJ. Gerontologists and the media: the dangers of over-pessimism. Biogerontology 2000;1(4):369-370.    PDF

de Grey ADNJ, Gavrilov L, Olshansky SJ, Coles LS, Cutler RG, Fossel M, Harman SM. Antiaging technology and pseudoscience. Science 2002; 296(5568):656.    PDF

de Grey ADNJ, Baynes JW, Berd D, Heward CB, Pawelec G, Stock G. Is human aging still mysterious enough to be left only to scientists? BioEssays 2002; 24(7):667-676.    PDF

de Grey ADNJ. Fear of misrepresentation cannot justify silence about foreseeable life-extension biotechnology. BioEssays 2003; 25(1):94-95.    PDF

de Grey ADNJ. The foreseeability of real anti-aging medicine: focusing the debate. Exp Gerontol 2003; 38(9):927-934.    PDF

de Grey ADNJ. Biogerontologists' duty to discuss timescales publicly. Annals NY Acad Sci 2004; 1019:542-545.    PDF

de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biol 2004; 2(6):723-726.    PDF

de Grey ADNJ. The war on aging. In: The Scientific Conquest of Death (B.J. Klein et al., eds.), Libros en Red, 2004, pp. 17-29. PDF Also translated into Spanish by Ana Centeno: "La guerra contra el envejecimiento".     PDF

de Grey ADNJ. Leon Kass: quite substantially right. Rejuvenation Res 2004; 7(2):89-91.    PDF

de Grey ADNJ. Three self-evident life-extension truths. Rejuvenation Res 2004; 7(3):165-167.    PDF

de Grey ADNJ. Aging, childlessness or overpopulation: the future's right to choose. Rejuvenation Res 2004; 7(4):237-238.    PDF

de Grey ADNJ. Life extension, human rights, and the rational refinement of repugnance. J Med Ethics 2005; 31(11):659-663.    PDF

de Grey ADNJ. Resistance to debate on how to postpone ageing is delaying progress and costing lives. EMBO Rep 2005; 6(S1):S49-S53.    PDF

de Grey ADNJ. Like it or not, life-extension research extends beyond biogerontology. EMBO Rep 2005; 6(11):1000.    PDF

de Grey ADNJ. When and where to publish important findings: a casualty of biogerontology's rise to respectability. Rejuvenation Res 2005; 8(1):1-2.    PDF

de Grey ADNJ. "The rate of aging": a counterproductively undefinable term. Rejuvenation Res 2005; 8(2):77-78.    PDF

de Grey ADNJ. The ethical status of efforts to postpone aging: a reply to Hurlbut. Rejuvenation Res 2005; 8(3):129-130.    PDF

de Grey ADNJ. The SENS challenge: $20,000 says the foreseeable defeat of aging is not laughable. Rejuvenation Res 2005; 8(4):207-210.    PDF

de Grey ADNJ. Compression of morbidity: the hype and the reality, part 1. Rejuvenation Res 2006; 9(1):1-2.    PDF

de Grey ADNJ. Compression of morbidity: the hype and the reality, part 2. Rejuvenation Res 2006; 9(2):167-168.    PDF

de Grey ADNJ. Has Hippocrates had his day? Rejuvenation Res 2006; 9(3):371-373.    PDF

de Grey ADNJ. SENS survives the Challenge; now let's get to work. Rejuvenation Res 2006; 9(4):429-430.    PDF

de Grey ADNJ. Is SENS a farrago? Rejuvenation Res 2006; 9(4):436-439.    PDF

de Grey ADNJ. The urgency dilemma: is life extension research a temptation or a test? Update 2006; 21(1):6-10.    PDF

de Grey ADNJ. The natural biogerontology portfolio: "defeating aging" as a multi-stage ultra-Grand Challenge. Annals NY Acad Sci 2007; 1100:409-423.    PDF

de Grey ADNJ. Aging and airborne HIV: a reassuring analogy. Rejuvenation Res 2007; 10(1):1-3.    PDF

de Grey ADNJ. Life span extension research and public debate: societal considerations. Studies in Ethics, Law and Technology 2007; 1(1):5.    PDF

de Grey ADNJ. Our right to life. J Evol Technol 2008; 17(2):53-57, in press.    PDF

de Grey ADNJ. Postponing aging: who are the experts? In: Tomorrow’s People, Proceedings of the 1st James Martin Institute World Forum (P. Healey, ed.), 2008, in press.    PDF

de Grey ADNJ. Understanding and tackling aging: two fields communicating (a little) at last. Rejuvenation Res 2007; 10(4):637-640.    PDF

de Grey ADNJ. Old people are people too: why it is our duty to fight aging to the death. Cato Unbound 2007(12): lead essay.    PDF

de Grey ADNJ. Is the quest to defeat aging ethical? In: Ethical Futures (S. Wint, ed.), 2008, in press.    PDF

de Grey ADNJ. Long live the unreasonable man. Rejuvenation Res 2008; 11(3):541-542.    PDF

Obviation of mitochondrial mutations:

de Grey ADNJ. Are those 13 proteins really unimportable? In: From Symbiosis to Eukaryotism - Endocytobiology VII (E. Wagner et al., eds.), Geneva University Press, 1999, pp. 489-502.

de Grey ADNJ. Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends Biotechnol 2000; 18(9):394-399.    PDF

de Grey ADNJ. Response to "approaches and limitations to gene therapy for mitochondrial diseases," Antioxid. Redox Signal. 2001;3:451-460. Antioxid Redox Signal 2001; 3(6):1153-1155.    PDF

de Grey ADNJ. Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutions. Rejuvenation Res 2004; 7(2): 95.98.    PDF

de Grey ADNJ. Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity? BioEssays 2005; 27(4):436-446.    PDF

Removal of lysosomal aggregates:

de Grey ADNJ. Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome. Trends Biotechnol 2002; 20(11): 452-455.    PDF

de Grey ADNJ, Alvarez PJJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev 2005; 4(3):315-338.    PDF

de Grey ADNJ. Lysosomal enhancement with microbial hydrolases: a novel strategy for removing protein aggregates. In: New Trends in Alzheimer and Parkinson Disorders: ADPD 2005 (A. Fisher et al., eds.), Medimond, 2005, pp. 51-54.     PDF

de Grey ADNJ. Appropriating microbial catabolism: a proposal to treat and prevent neurodegeneration. Neurobiol Aging 2006; 27(4):589-595.    PDF

de Grey ADNJ. Rejuvenating neurons and glia with microbial enzymes. In: Interaction Between Neurons and Glia in Aging and Disease (J.O. Malva et al., eds.), Springer, 2007, pp. 503-510.    PDF

de Grey ADNJ. Alzheimer’s, atherosclerosis, and aggregates: A role for bacterial degradation. Nutr Rev 2007; 65(12 Pt. 2):S221-S227.    PDF

A real cure for cancer, and why other nuclear mutations probably don't matter:

de Grey ADNJ, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CAB, Porter ACG. Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers. Annals NY Acad Sci 2004; 1019:147-170.    PDF

de Grey ADNJ. Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention. Front Biosci 2005; 10:2420-2429.    PDF

de Grey ADNJ. Protagonistic pleiotropy: why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging. Mech Ageing Dev 2007; 128(7-8):456-459.     PDF

Removing extracellular crosslinks and aggregates and unwanted cells:

de Grey ADNJ. Challenging but essential targets for genuine anti-ageing drugs. Expert Opinion on Therapeutic Targets 2003; 37(1):1-5.    PDF

de Grey ADNJ. Foreseeable pharmaceutical repair of age-related extracellular damage. Current Drug Targets 2006;7(11):1469-1477.     PDF

Mitochondrial mutations and their effects:

de Grey ADNJ. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays 1997; 19(2):161-166.    PDF

de Grey ADNJ. A mechanism proposed to explain the rise in oxidative stress during aging. J Anti-Aging Med 1998; 1(1):53-66.     PDF

de Grey ADNJ. The mitochondrial free radical theory of aging. Austin, TX: Landes Bioscience, 1999, 212pp, hardcover (ISBN 1-57059-564-X).

de Grey ADNJ. The non-correlation between maximum longevity and enzymatic antioxidant levels among homeotherms; implications for retarding human aging. J Anti-Aging Med 2000; 3(1):25-36.     PDF

de Grey ADNJ. The reductive hotspot hypothesis: an update. Arch Biochem Biophys 2000; 373(1):295-301.    PDF

de Grey ADNJ. The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief. Eur J Biochem 2002; 269(8):2003-2009.    PDF

de Grey ADNJ. Mitochondrial mutations in vertebrate aging. In: Oxidative stress and aging: advances in basic science, diagnostics, and intervention (R.G. Cutler and H. Rodriguez, eds.), World Scientific Publishing, 2002, pp. 437-451.     PDF

de Grey ADNJ. Mechanisms underlying the age-related accumulation of mutant mitochondrial DNA. In: Genetics of mitochondrial diseases (I.J. Holt, ed.), Oxford University Press, 2003, pp. 247-275.     PDF

de Grey ADNJ. Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention? Aging Cell 2004; 3(2):77.    PDF

de Grey ADNJ. Mitochondrial mutations in mammalian aging: an over-hasty about-turn? Rejuvenation Res 2004; 7(3):171-174.    PDF

de Grey ADNJ. Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulation. Rejuvenation Res 2005; 8(1):13-17.    PDF

de Grey ADNJ. The plasma membrane redox system: a candidate source of aging-related oxidative stress. AGE J Am Aging Assoc 2005; 27(2):129-138.     PDF

de Grey ADNJ. Free radicals in aging: causal complexity and its biomedical implications. Free Radic Res 2006; 40(12):1244-1249.     PDF

Other:

de Grey ADNJ. More on mitochondria and senescence: Response to Gershon. BioEssays 1997; 19(6):534-534.    PDF

de Grey ADNJ. Incorporation of transmembrane hydroxide transport into the chemiosmotic theory. Bioelectrochem Bioenerg 1999; 49(1-2):43-50.    PDF

de Grey ADNJ. Biologists abandon Popper at their peril. BioEssays 2000; 22(2):206-207.    PDF

de Grey ADNJ. A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion 2001; 1(2):129-139.    PDF

de Grey ADNJ. UK research on the biology of aging. Exp Gerontol 2001; 37(1):1-7.    PDF

de Grey ADNJ. Response to "telomere shortening with aging in human liver". J Gerontol A Biol Sci Med Sci 2001; 56(6):B237-B238.    PDF

de Grey ADNJ. HO₂: the forgotten radical. DNA Cell Biol 2002; 21(4):251-257.    PDF

de Grey ADNJ. Critique of the demographic evidence for "late-life non-senescence". Biochem Soc Trans 2003; 31(2):452-454.    PDF

de Grey ADNJ. A hypothesis for the minimal overall structure of the mammalian plasma membrane redox system. Protoplasma 2003; 221(1-2):3-9.    PDF

de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesis. Exp Gerontol 2003; 38(8):921-923.    PDF

de Grey ADNJ. Models on trial: falsifying overstated claims of generality does not falsify correctly-stated ones. Exp Gerontol 2004; 39(3):453.    PDF

de Grey ADNJ. Falsifying falsifications: the most critical task of theoreticians in biology. Medical Hypotheses 2004; 62(6):1012-1020.    PDF

de Grey ADNJ. The unfortunate influence of the weather on the rate of aging: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years. Gerontology 2005; 51(2):73-82.    PDF

de Grey ADNJ. Extrapolaholics Anonymous: why demographers' rejections of a huge rise in cohort life expectancy in this century are overconfident. Annals NY Acad Sci 2006; 1067:83-93.    PDF

de Grey ADNJ. Gene therapy. In: Encyclopedia of Aging, Fourth Edition (R. Schulz et al., eds.), Springer, 2006, pp. ???-???.    PDF

de Grey ADNJ. The case for prioritising research on late-onset life-extension interventions in mammals. Rejuvenation Res 2007; 10(3):257-259.    PDF

de Grey ADNJ. Edmonton: a future center for pioneering biomedical gerontology? Rejuvenation Res 2007; 10(3):345-347.    PDF

de Grey ADNJ. Calorie restriction, post-reproductive lifespan and programmed aging: a plea for rigor. Annals NY Acad Sci 2007; 1119:296-305.    PDF

de Grey ADNJ. The need to debalkanize gerontology: a case study. Rejuvenation Res 2007; 10(4):431-434.    PDF

Phoenix CR, de Grey ADNJ. A model of aging as accumulated damage matches observed mortality patterns and predicts the life-extending effects of prospective interventions. AGE 2007; 29(4):133-189.    PDF

de Grey ADNJ. Curiosity is addictive, and this is not necessarily a good thing. Rejuvenation Res 2008; 11(1):1-3.    PDF

de Grey ADNJ. Endless Youth. In: Eindeloos, 22ste Almanak der Groningse Farmaceutische Studenten Vereniging "Pharmaciae Sacrum" (I. Dubbelboer et al., eds.), 2008, pp. 22-27.    PDF

de Grey ADNJ. Consciousness in the context of radical life extension. In: Holistic Consciousness: Cognition, Memory, Individuality, Free Will, Zombies, Life, Death, Immortality and the Immune System (N. Bauer, ed.), 2008, in press.    PDF