August 23rd 2017

August 23, 2017

Antoxerene Closes $1.5M for Drug Discovery in Pathways of Aging

LAFAYETTE, NY: Today, Antoxerene, a pharmaceutical company that develops small molecule drugs for pathways of aging, announced the closing of an oversubscribed $1.5M seed round. Michael Greve’s Kizoo Technology CapitalSENS Research Foundation, and private investors participated in the round.

Drug screening is commonly performed in the life sciences to identify leads for drug development. However, several biologic pathways of known importance to aging are unable to be screened effectively because proteins necessary for the screen cannot be manufactured at sufficient purity and scale.

“This is an exciting time to be working on a drug discovery initiative,” stated Kelsey Moody, CEO at Antoxerene. “We believe that our next generation screens will have higher predictive value than traditional approaches, and for some pathways, could give us first on-target therapeutic candidates.”

Under a co-development deal with Finger Lakes BioAntoxerene has used proprietary RecombiPure expression technology to develop screens for the p53/MDM2 pathway, a major oncology target, and the p53/FOXO4 pathway, a newly identified pathway involved in cellular aging, among others.

“High-throughput drug screens are an essential component of any medical research program,” stated Aubrey de Grey, CSO of SENS Research Foundation, which participated in the financing round. “A focus on small molecule screens will make pivotal contributions in the development of a broad range of therapies to repair the damage of aging - real rejuvenation biotechnology.”

About Antoxerene

Antoxerene is a pharmaceutical company that uses proprietary next generation screening technology to identify small molecule compounds to target pathways of aging. The company is headquartered in LaFayette, NY and is an affiliate of Ichor Therapeutics, Inc. For more information see: antoxerene.com

About Kizoo Technology Capital

Kizoo helps young start-up teams grow by providing mentoring, seed and early stage financing with a growing focus on Rejuvenation Biotech. It is part of Michael Greve´s Forever Healthy initiative to enable people to vastly extend their healthy lifespans and be part of the first generation to cure aging. For more information see: kizoo.com

2017 SRF Summer Scholars Profiles Online

SENS Research Foundation is sponsoring a total of twelve internships at the Buck Institute for Research on Aging, the Harvard Stem Cell Institute, the Sanford Burnham Prebys Medical Discovery Institute, the Scripps Research Institute, the University of Oxford, and our very own SRF Research Center. Read on to learn a little more about our Summer Scholars and the research they are conducting. In this newsletter, we feature the interns being hosted at the SRF-RC. To view the full profile and project description for each Summer Scholar, click their name.

Amelia Anderson is pursuing a degree in biochemistry through the chemistry department at the University of California Santa Barbara (UCSB). Her summer project at SRF this year entails working with derivatives of drugs which have been shown to solubilize cholesterol and/or harmful derivatives of cholesterol such as oxysterols. She plans to eventually pursue a PhD in biochemistry and apply this doctorate to the field of education, pharmaceuticals, and/or environmental sustainability.
Jasmine Zhao is a rising senior at the University of California, Los Angeles majoring in Molecular, Cell, and Developmental Biology (MCDB) and minoring in biomedical research. She has worked in multiple labs over the past three years. Her summer project is being conducted under the mentorship of Dr. Amutha Boominathan and Dr. Matthew O’Connor at the SRF Research Center in Mountain View. The goal of this project is to design and test different constructs that can potentially improve the allotopic expression of ATP6 to mitochondria in mutant cell lines. After graduating from UCLA, she plans to pursue a career in medicine.

Michaela Copp is a rising senior studying Chemical Engineering at Vanderbilt University. She has been a member of the Neurovascular Engineering and Therapeutic Design lab under the direction of Dr. Ethan Lippmann for the past two years. This summer, she is working with the SRF Mitochondrial Team under the guidance of Dr. O’Connor and Dr. Boominathan. The objective of her research project is to establish a position in the genome capable of integrating new genetic material without posing a risk to the host cell in the nucleus for the expression of engineered mitochondrial genes. Moving forward, she aims to continue in biotechnological research and pursue a PhD in Bioengineering.

New Research Blog Post: Human Trials of Two New Rejuvenation Biotechnologies Targeting Alpha-Synuclein

by: Michael Rae

When we last reported news from Prothena Corp PLC, their cofounder and CEO Dr. Dale Schenk had recently presented the results of studies using their alpha-synuclein (AS)-targeting antibodies at SENS Research Foundation's Rejuvenation Biotechnology 2014 conference. Scientists at Prothena had confirmed that several of their candidate antibodies were able to clear AS pathology out of the brains and spinal cords of mouse models of Parkinson's Disease and related disorders, substantially shielding them against the PD-like motor and cognitive impairments suffered by their untreated cousins. Schenk also revealed some very early information specific to PRX002, the humanized version of the most promising antibody tested in the mouse studies, which was then slated to enter into early-stage human trials.

Werner CJ., Heyny-von Haussen R., Mall G., Wolf S., 

Histological sample of Substantia nigra in Parkinson's diseaseCC BY 2.0

Now we can report on the first published results of those trials, and on early information coming out of an additional trial that has not yet been formally published. Curious about the results? Read the full post on our website. 

Can You Take 3 Minutes To Tell The World About SENS Research Foundation?

If you support SENS Research Foundation's work toward real cures for age-related disease -- tell the world! Stories about us from people like you will help us make an even bigger impact in our community. GreatNonprofits – the #1 source of nonprofit stories and feedback – is honoring highly regarded nonprofits with their 2017 Top-Rated List. Won’t you help us raise visibility for our work by posting a brief story of your experience with us? All content will be visible to potential donors and volunteers. It’s easy and only takes 3 minutes. Go here to get started.

Where in the World is Aubrey de Grey?

Dr. Aubrey de Grey will be speaking at the following events:

Where: Amsterdam, Netherlands
When: September 1, 2017

The Dept Festival represents brief, energetic talks focused on creativity, data, and technology. 

Where: Boston, Massachusets, USA
When: October 27, 2017

[The] 2017 Connected Health Conference brings together the highly regarded Partners Connected Health Symposium and the PCHAlliance Connected Health Conference (formerly the mHealth Summit), to create the preeminent leadership gathering focused on the rapidly expanding field of technology-enabled health and wellness. 

Where: New York, New York, USA
When: November 1, 2017

Chaired by Economist editors, the event will bring together leaders from financial services, insurance, risk management and policy to discuss how best to adapt financial products, create new business strategies and re-align public policies to capitalise on the longevity economy.

 

 

 

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