Authors: 
D. van Heemst, on behalf of the Long Life Consortium
Category: 
Poster
Conference: 
Abstract: 

Tumour suppressor protein TP53 (p53) mediated induction of apoptosis and senescence plays a key role in protection against cancer. Mice deficient for p53 are highly susceptible to cancer, while mice with overactive p53 (p53 +/m) are almost cancerfree. However, despite their cancer resistance, the longevity of p53 +/m mice is reduced and accompanied by early tissue and organ atrophy, hinting at accelerated depletion of adult stem cell reserves (Nature 415, 45-53). These mouse models demonstrate that longevity may depend on a delicate balance between tumour suppression and tissue renewal mechanisms. Recently, Proline (Pro) variants of the p53 codon 72 polymorphism were shown to induce apoptosis less well than Arginine (Arg) variants in human cell lines. We found that in people aged 85 years and over the Pro/Pro genotype is associated with 41% increased late life survival (p

Keywords (Optional): 
longevity
cancer
p53