We established a mouse strain lacking Senescence Marker Protein-30 (SMP30). Its life span is shortened. With ageing the most organs of this strain show various phenomena such as lipid deposition, degeneration of mitochondria, prominent lysosomes, lipofuscin granules in comparison with wild type strain. This strain is more sensitive to apoptosis induction than wild type because of insufficiency of calcium pump activity in plasma membrane. Since SMP30 expression is modulated by oxidative stress, dietary restriction can enhance the amount of SMP30 in liver and kidney. SMP30 may protect the cells/organs from various injuries during life span. This mouse strain is a useful tool for ageing study.