Authors: 
Madeo F
Category: 
Invited
Conference: 
Abstract: 

Spermidine is a natural occurring polyamine that declines continuously during aging of organisms. We found that external administration of spermidine triggers autophagy across species and prolongs lifespan of yeasts, flies and worms in a autophagy dependent manner. Moreover, spermidine extends healthsspan of mice.

We propose that the anti-aging potential of spermidine roots in epigenetic transformation of the cell and indicate its therapeutic potential for the avoidance of age associated diseases.