The purpose of the present investigation was to measure the activity of acetylcholiesterase in discrete regions of young and aged rat brain before and after DL-a-lipoic acid supplementation. Two groups of male albino rats were used in this study (4 and 24 months of age). DL-a-lipoic acid was administered intraperitoneally with a regimen of 100 mg/kg body weight/day using alkaline saline as a vehicle for 7 and 14 days. The activity was measured in the cerebral cortex, cerebellum, striatum, hippocampus, and hypothalamus, and found to be significantly decreased in some of the brain regions in aged rats. Administration of lipoic acid into aged rats reversed the decrease in the activity in the discrete brain regions. Our results suggest that lipoic acid is effective in restoration of the activity of acetylcholiesterase in aged rats.
brain and acetylcholinesterase