Authors: 
V.E. Chernilevsky, A.N. Zajarny
Category: 
Poster
Conference: 
Abstract: 

Purpose, material and methods: The numerical experiment was carried out on a model of organism for valuation mechanisms of aging. Results: The cells (C) were substituted for deformable spheres in limited volume. Proliferation simulated by the doubling of C with the given coordinates. The moments and quantity of divisions, coordinates of C and form of limiting surfaces varied since a stage of zygota; connections of settlement points described by graph of conditional (GC) with tops - coordinates of the centres of C after the next division; the position of C calculated in accordance with the locally maximum dence packing as condition with a minimum potentional energy; distrophy, braking of C, apoptosis and telomeric effects (TE) simulated by absence of division in zone with critical density of C or with above critical number of divisions; the destruction of C exempted volume for the subsequent division in stages of morphogenesis; variants of GC without an opportunityof divisions meant how death, the immortalisation simulated at the expence of packing C and optimisation of GC life span at an expenditure of stem C as resource. It is established: death of C changes the packing, that prolong of GC at the expence of next divisions; initially lethal effects (LE) for C prolongs the GC life, apoptosis compensates LE of proliferation, TE compensates LE of limiting surfaces, the variants of packing determine length og GC d explain the difference in species life span, unlethal variants of packing were not revealed. Conclusion: These data allow to explain the effects of aging by regulator hypothesis.

Keywords (Optional): 
Cellular packing
Aging