Authors: 
J.R. Sparrow
Category: 
Invited
Conference: 
Abstract: 

Non-degradable autofluorescence pigments that accumulate in the retinal pigment epithelium (RPE) are implicated in the death of RPE cells in juvenile onset (Stargardt) macular degeneration and in the atrophic form of age-related macular degeneration. Our efforts are directed toward understanding the structures of these compounds, their biosynthetic pathways, factors that promote their formation and mechanisms by which they may damage the cell.

Keywords (Optional): 
retinal pigment epithelium
lipofuscin
retinoid-adducts
retinal degeneration