Spontaneous regression/complete resistant (SR/CR) mice are a line of cancer-resistant mice that are capable of resisting large doses of transplanted lethal cancer cells [1-3]. The basis for this powerful resistance to cancer cells is leukocytes that are capable of detecting, infiltrating, and killing cancer cells within a few hours of exposure . The major component of this anti-cancer response resides in granulocyte, monocyte, and natural killer cell fractions that constitute innate cellular immunity [1,2]. The adoptive transfer of donor leukocytes from SR/CR mice can confer protection against future exposures to cancer cells, as well as the elimination of established malignancies without any further manipulation in cancer-sensitive wild-type (WT) recipient mice . These prior studies suggested the possibility of developing a similar leukocyte transfer platform for humans if humans with anti-cancer activity similar to the SR/CR mice could serve as leukocyte donors. We obtained an FDA IND and WIRB approved Clinical trial for the novel Granulocyte/Leucocyte transfusion in Cancer Patients using young healthy donors. The development and ongoing status of this immunotherapy treatment for cancer will be presented.
1.Cui Z, et al: Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci USA 2003, 100(11):6682-6687.
2.Hicks AM, et al.: Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci USA 2006, 103(20):7753-7758.
3.Koch J,et al: Frequency of the cancer- resistant phenotype in SR/CR mice and the effect of litter seriation. In Vivo 2008, 22(5):565-569.