B.-M. Loeffler, E. Egorov

Intervall-hypoxia-therapy (IHT) is an in western medicine so far mostly unknown non-invasive therapeutic opportunity, even so that the physiological principles are at present already quit well understood down to the molecular level. With respective devices the concentration of oxygen in the breathable air is modulated between 21% (sea level) and 9% (+6500 m altitude) for defined periods. A novel element in this concept is the use of hyperoxia. Breathing air in alternating defined cycles with either decreased or increased (36% O2) O2 saturation does not only increase the O2 amplitude, but rather implements the modulation of additional physiological mechanisms, which improve cellular viability. Two principle mechanisms are modulated by hyoxia: a) The ability of the cell to store NO as Di-S-nitrosothiol-iron-complexes (DNIC) improve the physiological NO-reactivity and decreases the production of reactive nitrogene species (RNS). b) The activation of a plethora of hypoxia dependent genes, including those for erythropoetin, VEGF, VEGFR-1 and -2, Endothelin-1, iNOS, HOx-1, glycolysis enzymes, glucose transportes GLUT-1 and -3, iron metabolism, growth factors including TGF-b, PGF, PDGF-ß, HGF, apoptosis regulation factors Bcl-2, Mcl-1, Bax through the regulation of hypoxic-inducible-factor-1a (HIF-1a). On the other side hyperoxia although regulates on the gene expression level: ARE mediated phase-2 detoxifying ant antioxidant enzymes, IL8, IGFBP-2, ICAM-1, IL6, ENaC, p21, CCSP. Intervall-Hypoxia-Hyperoxia-Therapy (IHHT) is an advancement of classical IHT which broadens the impact of controled O2 partial pressure modulation on cell metabolism and discloses new treatment opportunities. The O2 partial pressure at the cellular, even more at the mitochondrial level, is of tremendous impact for the developement / treatment of chronic multi-system ilnesses. For example: The developement of OSA (obstructive sleep apnoe) is the consequence of an unregulated hypoxia. It leads amongst others to a therapy resistant hypertension. With heart-rate-variability controlled IHHT we could reverse the OSA in a patient with long standing OSA to normal and improve blood pressure and resting heart rate significantly. In a doulble-blind placebo controlled study with 10 IHHT treatment units of 35 minutes each we could show that the plasma Q10 level increased by 43% (p

Keywords (Optional): 
intervall hypoxia hyperoxia therapy
mitochondrial dysfunction
Coenzyme Q10
oxidative stress
anti aging