Authors: 
J.D. Furber
Category: 
Oral
Conference: 
Abstract: 

At first glance the wall chart, "Systems Biology of Human Aging Network", looks like a complicated web. However, as a conceptual summary, in one view, we can see how most biogerontological processes relate to each other. Importantly, examination of these relationships allows us to pick out reasonably plausible causal chains of events. Within these chains, we can see age-related changes (or accumulations) that appear to be promising targets for future therapy development. Especially harmful is damage to the body's regeneration and repair systems, because they normally repair damage to other structures and systems. Repairing the repair systems should receive high priority in planning the development of new therapies. An important example is age-associated growth of lipofuscin inside the lysosomes inside neurons. We will follow a pathway from age-associated causes down through the age-associated pathologies that result.

Keywords (Optional): 
Network
Causes
Pathway
Lysosome
Lipofuscin