Authors: 
J.D. Furber
Category: 
Oral
Conference: 
Abstract: 

Extracellular matrix (ECM) ages by several distinct mechanisms. This overview introduces the principal pathways and explores promising avenues for future therapy development. Pathways include: inflammatory glycoxidation and lipoxidation adducts: glycation crosslinks; amyloid deposits; protein residue isomerization, deamidation, and oxidation; fragmentation of collagen, elastin, laminin, and fibronectin; and loss of integrin binding sites. Promising future therapies could include drugs and enzymes that chemically repair the ECM, or cell therapies that biologically repair it.

Keywords (Optional): 
Extracellular matrix
integrin
glycation
elastin
cell therapy