Authors: 
L.A. Gavrilov, N.S. Gavrilova
Category: 
Oral
Conference: 
Abstract: 

In 1991 we suggested a scientific idea that living organisms are developing with an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of entire adult life (Gavrilov and Gavrilova, 1991, "The Biology of Life Span"; http://www.longevity-science.org/index.html#Book).

This idea of High Initial Damage Load (the HIDL hypothesis) predicts that even a small progress in optimizing the early-developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging-related morbidity and mortality, and significant extension of healthy lifespan (Gavrilov and Gavrilova, 2001, Journal of Theoretical Biology 213(4): 527-545; http://www.longevity-science.org/JTB-01.pdf). Thus, the idea of early-life programming of aging and longevity may have important practical implications for developing early-life interventions promoting health and longevity.

In this study we tested the predictions of High Initial Damage Load (HIDL) hypothesis. Specifically, the HIDL hypothesis predicts that early-life events may affect survival in later adult life through the level of initial damage. This prediction is confirmed for such early-life factors as paternal age at person's conception (Gavrilov and Gavrilova, 2003; http://www.longevity-science.org/Early-Life-Factors-2003.pdf) and the month of person's birth (Gavrilov and Gavrilova, 1999; http://www.longevity-science.org/Season-of-Birth.pdf).

Another testable prediction of the HIDL hypothesis is a prevision of an unusual non-linear pattern of lifespan inheritance. This prediction is tested and confirmed -- familial transmission of lifespan from parents to children follows a non-linear (accelerating) pattern with steeper slopes for offspring lifespan of longer-lived parents, as predicted (Gavrilova and Gavrilov 2001; http://www.longevity-science.org/JAAM-Boundaries-for-Human-Longevity.pdf).

Keywords (Optional): 
Aging Theory
Early-Life Programming
Parental Age
Season of Birth
Lifespan Inheritance