A. Budovsky, K. Muradian, V. Fraifeld

Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegenerative diseases, diabetes type II, osteoporosis, and sarcopenia. Although an apparent paradox, it appears that the most effective way to delay or even to avert the age-related pathology is to live longer. This is definitely exemplified by the phenomena of negligible senescence observed in certain species, exceptional longevity in humans, and by different experimental models of extended life span. On the other hand, early development and increased frequency of degenerative diseases are generally linked to accelerated aging. The mechanisms of aging and major degenerative diseases have much in common. We speculate that epigenetic modifications may be one of the central mechanisms behind both aging and age-associated pathologies. If so, the epigenetic interventions may serve in a two-fold way: (i) to extend the lifespan and (ii) cure age-related degenerative diseases. Altogether, these suggestions call for reconsidering of currently predominant view - from disease-oriented to aging/longevity-oriented studies

Keywords (Optional): 
lifespan extension