Authors: 
A. Bader, W. Brehm, C. Weber
Category: 
Invited
Conference: 
Abstract: 

Organiser's Note: The presenter of this talk withheld their permission for video to be published.


Regenerative medicine has led to completely new approaches and treatments of disease and injury. Regenerative medicine takes advantage of the healing potential already present in the individual, for example in the form of organ-specific stem cells. There are various techniques and approaches to regenerate tissue. They are able to adapt to the individual peculiarities of the patient. As a result we are on track to developing a tailor-made therapy for some important disease patterns.

Technical systems are applied such as bioreactors, hybrid systems (mixed systems, of two types of parentage, e.g. for the liver outside the body: autologous liver cells in small synthetic beads) and complete biological implants.

Since autologous tissue is immunologically better tolerated than exogenous tissue, the main aim is to achieve tissue regeneration in the living organism. Our area of research covers the search for a biological bone or rather cartilage replacement with autologous stem cells and mineralizing structures, for a biological liver replacement, for complete biological implants for a damaged heart, for example cardiac valves which when transplanted in children, grow with the child. In addition there are therapies supported by medication and novel growth factors to encourage the regeneration in living tissue.

In order to let the tissue grow e.g. outside the body, a type of extracellular scaffold of artificial or animal origin is needed. This so-called matrix is colonized with living cells of the patient. This colonization takes place in bioreactors that we have specially developed for this purpose. The conversion and replacement of the matrix with autologous tissue initiated in these bioreactors continues after the implant in the living organism.

Keywords (Optional): 
Regenerative Medicine
Bioreactors
Liver
Biological Implants
Tissue Engineering