Current science elucidates several consequences of normal metabolism within the neuron that partly determine aging damage to brain function; uncontrolled oxidation, chronic inflammation, and glycation. These consequences are influenced by several exogenous chemicals; R+ lipoic acid, acetyl-L carnitine, cytidine-diphosphate choline, N-acetyl cysteine, idebenone, docosahexaenoic acid, L carnosine, nicotine-adenine-dinucleotide hydrogen, turmeric, and salicylic acid, which may inhibit damage and facilitate neurogenesis.
Computer stimulated hormesis of brain function also facilitates fMRI verified neurogenesis and cognitive improvement, and may be obligatory for recovery of lost function. Combined chemical and computer stimulation intervention offers stronger manipulation than either source alone. Combination protocols are discussed with reference to cases of traumatic brain injury and senility, and use of cognition testing and neuroimaging technology to verify neurogenesis.