Authors: 
V. Golub, M. Golub
Category: 
Oral
Conference: 
Abstract: 

It is obvious enough that aging is a "product" of the individual development of an organism (even because development gives "material" for aging). Although there would be no aging without development, there seems to be an infinite dispute between those scientists who consider aging (or life expectancy) as a biological program and those who do not. According to our point of view, the aging of an organism begins only after its development is completed, and perhaps even later. There is an incredible quantity of examples of reversible arrest of the development in various organisms, from bacteria to mammals, caused by a “waiting” strategy. The essence of this type of strategy consists in switching the resources of an organism from reproduction to the maintenance of its own vitality, which thus makes a considerable increase in life expectancy possible. By investigating neobiosis (the reversible arrest of growth in dormice as an example of this kind strategy) and analyzing data of the various authors concerning the diapause mechanism in insects, we have reached conclusions concerning the key role that the circadian clock (localized in the SCN of the hypothalamus) plays in inducing the given condition. We have found and described cases of prolonged neobiosis (which are similar to superdiapause in some kinds of insects, for example, in the Emperor Moth). The stop and start of the molecular mechanism of the circadian clock occur only in certain phases of a daily cycle, and that can essentially facilitate the search for the factor which initiates neobiosis. Identification of biologically active substances which trigger the circadian clock-stopping mechanism can become the precondition for the creation of "non-maturing" mice and for experimental research of an interconnection between development and aging, and in the future can lead to the creation of technology aimed at total control over aging.

Keywords (Optional): 
neobiosis
SCN
circadian clock
superdiapause
control over aging