Lowering body temperature (Tb) still remains the most efficient and reliable way for life span extension in exotherms. Several lines of evidence suggest that a moderate decrease in Tb could have a profound longevity-promoting effect in endotherms as well. This effect is a typical example of systemic interventions, with self-rearrangement at all levels of biological organization of an organism. In mediating the effects of Tb on life span, the two major determinants of mammalian longevity, mitochondrial DNA (mtDNA) GC content and metabolic rate (Lehmann et al., Rejuvenation Res 2008; 11:409-417) appear to be of particular significance. Because of the ability of the thermoregulatory center to escape long-term suppression, a periodic decrease in Tb (for example, during sleeping) may represent an alternative and technically feasible strategy. Our calculations show that even a moderate decrease in Tb could result in a dramatic extension of human life span.
life span extension