A convincing link between oxidative stress and neurodegenerative condtions has been made with the knowledge that oxidative changes may actually trigger deterioration in cellular functions. We analysed the effect of DL-alpha-lipoic acid on the level of lipofuscin and the activity of sodium pottasium ATPase in discrete brain regions of young and aged rats. In aged rats, the level of lipofuscin was high, while the activity of sodium potassium ATPase was low. Intraperitoneal administration of alpha lipoic acid to aged rats led to a duration-dependent reduction in the content of lipofuscin and an elevation in the activity of sodium potassium ATPase in several brain regions including the cortex, cerebellum, striatum, hippocampus and hypothalamus. There reslts suggest that lipoic acid, a metabolic antioxidant, can be a useful therapeutic tool in improving neuronal functions of aged individuals.
alpha lipoic acid